Luvox CR

Generic name: Fluvoxamine
Drug class: Selective serotonin reuptake inhibitors

Usage of Luvox CR

Fluvoxamine is used to treat obsessive compulsive disorder (OCD). It belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain. .

This medicine is available only with your doctor's prescription.

Luvox CR side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

Less common

Behavior, mood, or mental changes

delayed or inability to have an orgasm

trouble with breathing

trouble with urinating

twitching

Rare

Absence of or decrease in body movements

agitation

blurred vision

chills

clumsiness or unsteadiness

confusion

diarrhea

fever

inability to move the eyes

increase in body movements

menstrual changes

nosebleeds

overactive reflexes

poor coordination

red or irritated eyes

redness, tenderness, itching, burning, or peeling of the skin

restlessness

seizures

shivering

skin rash

sore throat

sweating

talking or acting with excitement you cannot control

trembling or shaking

unusual bruising

unusual, incomplete, or sudden body or facial movements

unusual secretion of milk (in females)

weakness

Incidence not known

Agitation

anger

bloating

chest tightness

constipation

cough

difficulty swallowing

darkened urine

fast heartbeat

headache

hostility

indigestion

irritability

loss of appetite

nausea

pains in the stomach, side, or abdomen, possibly radiating to the back

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

swelling of the breasts or unusual milk production

vomiting

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Change in sexual performance or desire

trouble sleeping

unusual tiredness

Less common

Change in sense of taste

decreased appetite

feeling of constant movement of self or surroundings

frequent urination

heartburn

increased sweating

stomach pain

unusual weight gain or loss

Incidence not known

Decrease in smell

loss of sense of smell

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Luvox CR

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluvoxamine tablets in children 8 to 17 years of age. Because fluvoxamine may cause weight loss or a decrease in appetite, children who will be taking fluvoxamine for a long time should have their weight and growth measured by the doctor regularly.

Appropriate studies have not been performed on the relationship of age to the effects of fluvoxamine extended-release capsules in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluvoxamine in the elderly. However, elderly patients are more likely to have hyponatremia (low sodium in the blood) and age-related liver problems, which may require an adjustment in the dose for patients receiving fluvoxamine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Agomelatine

Alosetron

Astemizole

Bromopride

Cisapride

Eliglustat

Fezolinetant

Isocarboxazid

Levomethadyl

Linezolid

Mavacamten

Methylene Blue

Metoclopramide

Ozanimod

Phenelzine

Pimozide

Procarbazine

Ramelteon

Rasagiline

Safinamide

Selegiline

Terfenadine

Thioridazine

Tizanidine

Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

ABCiximab

Abrocitinib

Acalabrutinib

Aceclofenac

Acemetacin

Acenocoumarol

Alfentanil

Almotriptan

Alprazolam

Amineptine

Amiodarone

Amitriptyline

Amitriptylinoxide

Amoxapine

Amphetamine

Amtolmetin Guacil

Anagrelide

Anileridine

Apixaban

Aprepitant

Ardeparin

Argatroban

Asenapine

Aspirin

Atazanavir

Avapritinib

Belzutifan

Bemiparin

Bendamustine

Benzhydrocodone

Benzphetamine

Betrixaban

Bivalirudin

Bosutinib

Brigatinib

Bromfenac

Brompheniramine

Bufexamac

Butorphanol

Carvedilol

Celecoxib

Certoparin

Chlorpheniramine

Choline Salicylate

Cilostazol

Citalopram

Clomipramine

Clonixin

Clopidogrel

Clorgyline

Clozapine

Cobicistat

Cocaine

Codeine

Colchicine

Cyclobenzaprine

Dabigatran Etexilate

Dalteparin

Danaparoid

Daridorexant

Darunavir

Deflazacort

Desipramine

Desirudin

Desmopressin

Desvenlafaxine

Dexfenfluramine

Dexibuprofen

Dexketoprofen

Dextroamphetamine

Dextromethorphan

Diazepam

Dibenzepin

Diclofenac

Difenoxin

Diflunisal

Dihydrocodeine

Dihydroergotamine

Diphenoxylate

Dipyridamole

Dipyrone

Dolasetron

Domperidone

Donepezil

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Droxicam

Duloxetine

Edoxaban

Elacestrant

Eletriptan

Elexacaftor

Encorafenib

Enoxaparin

Entrectinib

Epoprostenol

Eptifibatide

Ergoloid Mesylates

Ergonovine

Ergotamine

Escitalopram

Ethylmorphine

Etodolac

Etofenamate

Etoricoxib

Everolimus

Fedratinib

Felbinac

Fenfluramine

Fenoprofen

Fentanyl

Fepradinol

Feprazone

Fexinidazole

Finerenone

Floctafenine

Flufenamic Acid

Fluoxetine

Flurbiprofen

Fondaparinux

Fosaprepitant

Frovatriptan

Gepirone

Granisetron

Heparin

Hydrocodone

Hydromorphone

Hydroxytryptophan

Ibrutinib

Ibuprofen

Iloprost

Imipramine

Indomethacin

Infigratinib

Iobenguane I 123

Iobenguane I 131

Ivacaftor

Ivosidenib

Ketobemidone

Ketoprofen

Ketorolac

Lasmiditan

Lemborexant

Lepirudin

Levomilnacipran

Levorphanol

Lisdexamfetamine

Lithium

Lofepramine

Lorcaserin

Lornoxicam

Loxoprofen

Lumateperone

Lumiracoxib

Lurbinectedin

Meclofenamate

Mefenamic Acid

Melatonin

Melitracen

Meloxicam

Meperidine

Metaxalone

Methadone

Methamphetamine

Methylergonovine

Methylphenidate

Milnacipran

Mirtazapine

Mitapivat

Mobocertinib

Morniflumate

Morphine

Morphine Sulfate Liposome

Nabumetone

Nadroparin

Nalbuphine

Naproxen

Naratriptan

Nefazodone

Nepafenac

Nialamide

Nicomorphine

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Nortriptyline

Olanzapine

Olaparib

Omaveloxolone

Ondansetron

Opipramol

Opium

Opium Alkaloids

Ospemifene

Oxaprozin

Oxycodone

Oxymorphone

Oxyphenbutazone

Pacritinib

Palonosetron

Palovarotene

Papaveretum

Parecoxib

Paregoric

Parnaparin

Paroxetine

Pemigatinib

Pentazocine

Pexidartinib

Phenindione

Phenobarbital

Phenprocoumon

Phenylbutazone

Piketoprofen

Piperaquine

Pirfenidone

Piritramide

Piroxicam

Pixantrone

Pomalidomide

Pralsetinib

Pranoprofen

Prasugrel

Primidone

Proglumetacin

Propyphenazone

Proquazone

Protein C

Protriptyline

Remifentanil

Reviparin

Rimegepant

Rivaroxaban

Rizatriptan

Rofecoxib

Salicylic Acid

Salsalate

Selexipag

Selumetinib

Sertraline

Sibutramine

Sirolimus Protein-Bound

Sodium Salicylate

Sonidegib

Sparsentan

St John's Wort

Sufentanil

Sulfinpyrazone

Sulindac

Sulodexide

Sumatriptan

Tacrolimus

Tamoxifen

Tapentadol

Tasimelteon

Tazemetostat

Tenoxicam

Tezacaftor

Theophylline

Tianeptine

Tiaprofenic Acid

Ticagrelor

Ticlopidine

Tilidine

Tinzaparin

Tirofiban

Tolfenamic Acid

Tolmetin

Toloxatone

Tolvaptan

Tramadol

Trazodone

Treprostinil

Triclabendazole

Trimipramine

Tryptophan

Ubrogepant

Valdecoxib

Venetoclax

Venlafaxine

Vilazodone

Voclosporin

Vorapaxar

Vortioxetine

Warfarin

Zanubrutinib

Ziprasidone

Zolmitriptan

Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amlodipine

Cyclosporine

Fosphenytoin

Galantamine

Ginkgo

Haloperidol

Mexiletine

Midazolam

Phenytoin

Propranolol

Roflumilast

Ropivacaine

Suvorexant

Tacrine

Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Tobacco

Relate drugs

How to use Luvox CR

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Fluvoxamine may be taken with or without food. Take this medicine at bedtime, unless your doctor tells you otherwise.

Swallow the extended-release capsule whole. Do not crush, break, or chew it.

You might have to take this medicine for several months before you begin to feel better.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of obsessive-compulsive disorder:

For oral dosage form (extended-release capsules):

Adults—At first, 100 milligrams (mg) once a day at bedtime. Your doctor may adjust your dose as needed. However, the dose is usually not more than 300 mg per day.

Children—Use and dose must be determined by your doctor.

For oral dosage form (tablets):

Adults—At first, 50 milligrams (mg) once a day at bedtime. Your doctor may adjust your dose as needed. However, the dose is usually not more than 300 mg per day. If your daily dose is higher than 100 mg, your doctor may want you to take it in 2 divided doses.

Children 8 to 17 years of age—At first, 25 mg once a day at bedtime. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg or 300 mg per day based on age. If your daily dose is higher than 50 mg, your doctor may want you to take it in 2 divided doses.

Children younger than 8 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits. This will allow for changes in the dose and to help reduce any side effects. Blood tests may be needed to check for unwanted effects.

Do not take alosetron (Lotronex®), pimozide (Orap®), ramelteon (Rozerem®), thioridazine (Mellaril®), or tizanidine (Zanaflex®) while you are taking fluvoxamine. You could have more side effects than usual if you use these medicines together.

Do not take fluvoxamine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid [Zyvox®], methylene blue injection, phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking fluvoxamine during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping fluvoxamine before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures.

Fluvoxamine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use fluvoxamine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. John's wort, amphetamines, or some pain or migraine medicines (eg, meperidine, methadone, rizatriptan, sumatriptan, tramadol, Demerol®, Methadose®, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®). Check with your doctor first before taking any other medicines with fluvoxamine.

Fluvoxamine may cause some people to be agitated, irritable or display other abnormal behaviors. It may also cause some children, teenagers, and young adults to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you, or your caregiver notice any of these side effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

Avoid drinking alcohol with fluvoxamine.

This medicine may cause some people to become drowsy, less able to think clearly, or to have blurred vision or poor muscle control. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to see clearly.

Do not suddenly stop taking this medicine without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. This is to decrease the chance of having withdrawal symptoms such as agitation, confusion, headache, irritability, numbness or tingling, restlessness, trouble sleeping, or unusual drowsiness or weakness.

This medicine may increase your risk for bleeding problems. Make sure your doctor knows if you are also taking other medicines that thin the blood, including aspirin, NSAIDs (eg, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or warfarin (Coumadin®, Jantoven®).

Hyponatremia (low sodium in the blood) may occur with this medicine. Check with your doctor right away if you have confusion, difficulty concentrating, headaches, memory problems, weakness, and unsteadiness.

Tell your doctor right away if you develop a rash or hives, swelling of the face, eyes, or mouth, or trouble breathing after taking this medicine.

Check with your doctor right away if you have decreased interest in sexual intercourse, delayed or inability to have an orgasm in women, inability to have or keep an erection in men, or loss in sexual ability, desire, drive, or performance. These could be symptoms of sexual dysfunction.

Some men and women who use this medicine have become infertile (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

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