Mafenide

Generic name: Mafenide
Drug class: Topical antibiotics

Usage of Mafenide

Mafenide, a sulfa medicine, is used to prevent and treat bacterial or fungus infections. It works by preventing growth of the fungus or bacteria.

Mafenide cream is applied to the skin and/or burned area(s) to prevent and treat bacterial or fungus infections that may occur in burns.

Other medicines are used along with this medicine for burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital.

This medicine is available only with your doctor's prescription.

Mafenide side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Itching

skin rash or redness

swelling of face or skin

wheezing or troubled breathing

Rare

Bleeding or oozing of skin

drowsiness

fast, deep breathing

nausea

Incidence unknown

Black, tarry stools

chest pain

chills

cough or hoarseness

dark urine

dizziness

fever

fluid-filled skin blisters

light-colored stools

lower back or side pain

numbness to feet, hands and around mouth

painful or difficult urination

rapid shallow breathing

sensitivity to the sun

shortness of breath

skin thinness

sore throat

sores, ulcers, or white spots on lips or in mouth

swollen glands

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Pain or burning feeling on treated area(s)

Incidence unknown

Blisters

flushing

raised red swellings on the skin, lips, tongue, or in the throat

redness of skin

skin rash

softening of the skin

swelling

unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Mafenide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever HAD any unusual or allergic Reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of mafenide is not recommended in premature or newborn infants up to 2 months of age. Sulfa medicines may cause liver problems in these infants.

Geriatric

Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the SAMe way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mafenide in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Methenamine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Methotrexate

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aminolevulinic Acid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Mafenide

To use:

Before applying this medicine, cleanse the affected area(s). Remove dead or burned skin and other debris.

Wear a sterile glove to apply this medicine. For the topical creak, apply a thin layer (about 1/16 inch) of mafenide to the affected area(s). For the topical solution, the solution is applied to the dressing covering the affected area(s). Keep the affected area(s) covered with the medicine at all times.

If this medicine is rubbed off the affected area(s) by moving around or if it is washed off during bathing, showering, or the use of a whirlpool bath, reapply the medicine.

After this medicine has been applied, the treated area(s) may be covered with a dressing or left uncovered as desired.

To help clear up your skin and/or burn infection completely, keep using mafenide for the full time of treatment. You should keep using this medicine until the burn area has healed or is ready for skin grafting. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take Depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical doSage form (cream):

For bacterial or fungus infection:

Adults and children 2 months of age and over—Use one or two times a day.

Infants and children up to 2 months of age—Use is not recommended.

For topical dosage form (solution):

For bacterial or fungus infection:

Adults and children 3 months of age and over—Use every 4 to 8 hours each day as needed to keep the dressing wet.

Infants and children up to 3 months of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Warnings

It is important that your doctor check your progress at regular visits.

If your skin infection or burn does not improve within a few days or if your more serious burns or burns over larger areas do not improve within a few weeks, or if they become worse, check with your doctor.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.