Margenza

Generic name: Margetuximab
Drug class: HER2 inhibitors

Usage of Margenza

Margenza is a human epidermal growth factor receptor (HER2) inhibitor that slows or stops cell growth.

Margenza injection is used in combination with other cancer drugs to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic).

Margenza is for use in people who have received at least two prior chemotherapy treatments for HER2-positive breast cancer.

Your doctor will test to make sure your cancer has an abnormal "HER2/neu" gene (a specific genetic marker).

Margenza side effects

Get emergency medical help if you have signs of an allergic Reaction to Margenza: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, tired, nauseated, light-headed, itchy, sweaty, feverish, chilled, or have a headache, rash, joint pain, cough fast heartbeats, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

new or worsening cough;

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

heart problems - pounding heartbeats, dizziness, swelling in your face or lower legs, rapid weight gain (more than 5 pounds in 1 day), feeling short of breath;

hand-foot syndrome - pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet; or

low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Common Margenza side effects may include:

feeling weak or tired;

stomach pain, nausea, vomiting, loss of appetite;

diarrhea, constipation;

fever;

hair loss;

headache;

cough, trouble breathing;

pain, numbness, or tingling in your arms or legs;

muscle or joint pain;

hand-foot syndrome; or

side effects during the injection.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Margenza

Margenza may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant. Keep using birth control for at least 4 months after your last dose.

You may need to have a negative pregnancy test before starting this treatment.

It may not be safe to breastfeed while using Margenza, and for at least 4 months after your last dose. Ask your doctor about any risk.

Tell your doctor if you have ever had heart problems.

Relate drugs

How to use Margenza

Usual Adult Dose for Breast Cancer:

15 mg/kg IV every 3 weeks Comment: -Infuse initial dose over 120 minutes and subsequent doses over 30 minutes. -This drug may be administered immediately after the completion of chemotherapy. -Continue treatment until disease progression or unacceptable toxicity. -All therapeutic proteins, including this drug, have the potential to produce an immune response. Use: In combination with chemotherapy, for the treatment of adult patients with metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 regimens, at least one of which was for metastatic disease

Warnings

Margenza may cause heart problems. Call your doctor at once if you have symptoms such as: fast or pounding heartbeats, cough, shortness of breath, swelling, or rapid weight gain.

Margenza can cause harm to the unborn baby if used while pregnant. Effective contraception must be used during treatment and for 4 months following the last dose.

What other drugs will affect Margenza

Margetuximab can have long-lasting effects on your body. For at least 4 months after your last dose of Margenza, you should not be treated with certain other cancer drugs. Tell each of your doctors about your treatment with this medicine.

Other drugs may interact with margetuximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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