Mavacamten
Generic name: Mavacamten
Brand names: Camzyos
Dosage form: oral capsule (10 mg; 15 mg; 2.5 mg; 5 mg)
Drug class:
Miscellaneous cardiovascular agents
Usage of Mavacamten
Mavacamten is used in adults to treat a heart problem called obstructive hypertrophic cardiomyopathy (HCM). mavacamten may improve people's symptoms and their ability to be active.
Mavacamten is available only from a certified pharmacy under a special program. You must be registered in the program and understand the risks and benefits of this medicine.
Mavacamten may also be used for purposes not listed in this medication guide.
Mavacamten side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Mavacamten may cause serious side effects. Call your doctor at once if you have:
Common side effects of mavacamten may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Mavacamten
Some drugs should not be used with mavacamten. Your treatment plan may change if you also use:
Tell your doctor if you have ever had:
Mavacamten may harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using mavacamten and for at least 4 months after your last dose. Tell your doctor if you become pregnant.
Ask a doctor if it is safe to breastfeed while using mavacamten.
Mavacamten can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.
Relate drugs
- Corlanor
- Camzyos
- Demser
- Dibenzyline
- Filspari
- Inpefa
- Ivabradine
- Mavacamten
- Metyrosine
- Midodrine
- Orvaten
- Phenoxybenzamine
- Phentolamine
- Proamatine
- Regitine
- Sotagliflozin
- Sparsentan
How to use Mavacamten
Usual Adult Dose for Hypertrophic Cardiomyopathy:
Starting dose: 5 mg orally once a dayAllowable subsequent doses with titration: 2.5, 5, 10, or 15 mg orally once a dayComments:-Patients may develop heart failure while taking this drug; regular left ventricular ejection fraction (LVEF) and Valsalva left ventricular outflow tract (LVOT) gradient assessment is needed for careful titration to achieve an appropriate target Valsalva LVOT gradient, while maintaining LVEF at least 50% and avoiding heart failure symptoms.-When initiating or titrating this drug, LVEF should be considered first, then the Valsalva LVOT gradient and patient clinical status should be considered to guide appropriate dosing; the algorithms for INITIATION and MAINTENANCE should be followed for appropriate dosing and monitoring schedules.-If LVEF is less than 50% during therapy, this drug should be interrupted; the algorithm for INTERRUPTION should be followed for guidance on interrupting, restarting, or discontinuing this drug. If interrupted at 2.5 mg, the patient should either restart at 2.5 mg or permanently discontinue this drug.Use: For the treatment of patients with symptomatic New York Heart Association (NYHA) class II to III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms
Warnings
Call your doctor at once if you have shortness of breath, chest pain, tiredness, swelling in your legs, rapid weight gain, or racing or pounding heartbeats.
What other drugs will affect Mavacamten
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect mavacamten, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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