Mavenclad
Generic name: Cladribine (oral)
Drug class:
Antimetabolites
Usage of Mavenclad
Mavenclad is a purine antimetabolite that interferes with enzymes that are necessary for DNA synthesis.
Mavenclad is used to treat relapsing multiple sclerosis (MS) in adults. This medicine will not cure MS, it will only decrease the frequency of relapse symptoms.
Mavenclad is usually given after other treatments have failed.
Mavenclad side effects
Get emergency medical help if you have signs of an allergic reaction to Mavenclad: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Mavenclad may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.
Also call your doctor at once if you have:
Common Mavenclad side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Mavenclad
You should not take Mavenclad if you are allergic to cladribine, or if you have:
To make sure Mavenclad is safe for you, tell your doctor if you have ever had:
Tell your doctor if you have recently received a vaccine (within 4 to 6 weeks before you take Mavenclad).
Taking cladribine may increase your risk of developing certain cancers. Ask your doctor about this risk.
Do not take Mavenclad if you are pregnant. Cladribine could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
Mavenclad can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while taking this medicine, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Keep using the second form of birth control for at least 4 weeks after your Mavenclad treatment course ends.
Do not breastfeed while taking cladribine, and for at least 10 days after your last dose.
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How to use Mavenclad
Take Mavenclad exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Your doctor will perform medical tests to make sure you do not have conditions that would prevent you from safely using Mavenclad.
Mavenclad is taken in 2 treatment courses separated by about a year. There are 2 treatment cycles in each course. During each cycle, you will take the medicine for 4 or 5 days in a row. The 2 cycles are separated by about a month. Follow your doctor's dosing instructions very carefully.
Your doctor will determine how many treatment courses you should receive.
Take this medicine with a full glass of water. You may take Mavenclad with or without food.
Use dry hands to remove a tablet from the foil blister pack when you are ready to take the medicine.
Swallow the tablet whole and do not crush, chew, or break it.
Wash your hands after handling the tablet.
Do not use a broken tablet. The medicine from a broken pill can be dangerous if it gets in your eyes or nose, or on your skin. If this happens, rinse thoroughly with water. Ask your pharmacist how to safely dispose of a broken pill.
You may be given other medications to help prevent infections. Keep using these medicines for as long as your doctor has prescribed.
You will need frequent medical tests, and your next dose may be delayed based on the results.
Store at room temperature away from moisture and heat.
Cladribine can have long lasting effects on your body. Your doctor will need to check your progress on a regular basis and for another 2 years after your last dose.
Warnings
Do not take Mavenclad if you are pregnant. Both men and women should use effective birth control to prevent pregnancy while taking Mavenclad, and for 6 months after the last dose.
If you use birth control pills or other hormonal forms (implants, skin patches, vaginal rings), also use a barrier form of birth control (condom, diaphragm, cervical cap, contraceptive sponge) to prevent pregnancy while taking Mavenclad and for at least 4 weeks after your treatment course ends.
Taking cladribine may increase your risk of developing certain cancers.
What other drugs will affect Mavenclad
If you take any other medicines by mouth, take your Mavenclad dose 3 hours before or 3 hours after you take the other medicine.
Other drugs may interact with cladribine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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