Megace

Generic name: Megestrol

Usage of Megace

Megestrol tablet is used to treat advanced cancer of the breast or uterus in patients whose cancer has already spread, come back, or cannot be treated with surgery. Megestrol oral liquid is also used to treat anorexia, cachexia, or unexplained weight loss in patients with acquired immunodeficiency syndrome (AIDS).

This medicine is available only with your doctor's prescription.

Megace side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Blurred vision
  • dizziness
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • nausea
  • nervousness
  • slow or fast heartbeat
  • stomach pain
  • sweating
  • trouble breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting

    • Less common

  • Black, tarry stools
  • bladder pain
  • bloody or cloudy urine
  • burning or stinging of the skin
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • chest pain or discomfort
  • cough or hoarseness
  • discouragement
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling sad or empty
  • fever or chills
  • frequent urge to urinate
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • lower back or side pain
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • painful or difficult urination
  • right upper abdominal or stomach pain and fullness
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stabbing pain
  • swelling
  • swelling of the breasts or breast soreness in both females and males
  • swelling of the feet or lower legs
  • swollen glands
  • trouble concentrating
  • trouble sleeping
  • tumor
  • unusual bleeding or bruising

    • Incidence not known

  • Anxiety
  • backache
  • changes in skin color
  • facial hair growth in females
  • fractures
  • hives, itching, rash
  • joint or muscle pain
  • loss of sexual desire or ability
  • menstrual irregularities
  • muscle wasting
  • pain, tenderness, or swelling of the foot or leg

    • Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common

  • Acid or sour stomach
  • belching
  • decreased interest in sexual intercourse
  • excess air or gas in the stomach or intestine
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • stomach discomfort or upset

    • Less common

  • Abnormal thinking
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • change in vision
  • constipation
  • increased salivation

    • Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Before taking Megace

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Allergies

    Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

    Pediatric

    Appropriate studies have not been performed on the relationship of age to the effects of megestrol in the pediatric population. Safety and efficacy have not been established.

    Geriatric

    Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of megestrol in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

    Breast Feeding

    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Interactions with Medicines

    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dofetilide

    • Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Warfarin

    • Interactions with Food/Tobacco/Alcohol

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

    Other Medical Problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Adrenal problems (eg, Cushing's syndrome) or
  • Blood clots, history of or
  • Diabetes—Use with caution. May make these conditions worse.
  • Cancer or
  • Endocrine disease or
  • Infection or
  • Kidney disease or
  • Mental problems or
  • Stomach or bowel problems—Megestrol oral liquid is not indicated to prevent weight loss in these patients.

    • How to use Megace

    Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

    For cancer treatment, you may need to take the tablets for at least 2 months before it starts to work.

    Measure the oral liquid medicine with a marked measuring spoon. Shake well before using.

    Dosing

    The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take Depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
  • For breast cancer:
  • Adults—40 milligrams (mg) 4 times a day for at least 2 months.
  • Children—Use and dose must be determined by your doctor.
  • For uterine cancer:
  • Adults—40 milligrams (mg) to 320 mg taken in divided doses per day for at least 2 months.
  • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (suspension):
  • For treatment of anorexia, cachexia, or unexplained weight loss in patients with AIDS:
  • Adults—625 milligrams (mg) (5 milliliters [mL] or 1 teaspoon) per day.
  • Children—Use and dose must be determined by your doctor.

    • Missed Dose

    If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    Storage

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Warnings

    It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

    Using megestrol oral liquid while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Use an effective form of birth control during treatment with this medicine. If you think you have become pregnant while using this medicine, tell your doctor right away.

    This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

    This medicine may cause diabetes. Check with your doctor right away if you have blurred vision, dry mouth, flushed, dry skin, fruit-like breath odor, increased hunger, increased thirst, increased urination, loss of consciousness, nausea, stomach pain, sweating, trouble breathing, unexplained weight loss. or vomiting.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

    Disclaimer

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