Mekinist
Generic name: Trametinib
Drug class:
Multikinase inhibitors
Usage of Mekinist
Mekinist is used alone or in combination with dabrafenib (Tafinlar) to treat certain types of melanoma (a type of skin cancer).
Mekinist is also used in combination with dabrafenib to prevent the return of a certain type of melanoma after surgery. Mekinist is also used in combination with dabrafenib to treat certain types of non-small-cell lung cancer (NSCLC) and thyroid cancer.
Mekinist is also used in combination with dabrafenib to treat certain types of solid tumors in adults and children 6 years of age older and to treat a certain type of glioma (a certain type of cancerous brain tumor) in children 1 year of age or older.
Trametinib belongs to a class of medications called kinase inhibitors. Mekinist works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
Mekinist is often given when the cancer has spread to other parts of the body, when surgery is not an option, or to keep the cancer from coming back after surgery.
Your doctor will make sure you have the correct tumor type to be treated with Mekinist.
Mekinist side effects
Get emergency medical help if you have signs of an allergic reaction to Mekinist (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Some people taking Mekinist have developed a perforation (a hole or tear) or swelling in the stomach or intestines. Call your doctor if you have severe stomach pain, bleeding, diarrhea, fever, or nausea.
Mekinist may cause serious side effects. Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Mekinist side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Mekinist
To make sure Mekinist is safe for you, tell your doctor if you have ever had:
Using Mekinist may increase your risk of developing other cancers. Ask your doctor about this risk.
Trametinib can harm an unborn baby if the mother or the father is using Mekinist.
Do not breastfeed while using Mekinist, and for at least 4 months after your last dose.
Relate drugs
- Afatinib
- Alecensa
- Alectinib
- Alunbrig
- Avapritinib
- Ayvakit
- Cobimetinib
- Cotellic
- Crizotinib
- Balversa
- Binimetinib
- Braftovi
- Brigatinib
- Capmatinib
- Ceritinib
- Dabrafenib
- Deucravacitinib
- Encorafenib
- Entrectinib
- Erdafitinib
- Fedratinib
- Futibatinib
- Gavreto
- Gilotrif
- Gilteritinib
- Infigratinib
- Inrebic
- Jakafi
- Koselugo
- Larotrectinib
- Litfulo
- Lorbrena
- Lorlatinib
- Lytgobi
- Mekinist
- Mektovi
- Midostaurin
- Momelotinib
- Nintedanib
- Ofev
- Ojjaara
- Pacritinib
- Pemazyre
- Pemigatinib
- Pexidartinib
- Pralsetinib
- Qinlock
- Retevmo
- Ripretinib
- Ritlecitinib
- Rozlytrek
- Ruxolitinib
- Ruxolitinib (Oral)
- Rydapt
- Selpercatinib
- Selumetinib
- Sotyktu
- Tabrecta
- Tafinlar
- Tepmetko
- Tepotinib
- Trametinib
- Truseltiq
- Turalio
- Ukoniq
- Umbralisib
- Vemurafenib
- Vitrakvi
- Vonjo
- Xalkori
- Xospata
- Zelboraf
- Zykadia
How to use Mekinist
Take Mekinist exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Take once per day on an empty stomach, at least 1 hour before or 2 hours after a meal.
Swallow the tablet whole and do not crush, chew, or break it.
If you vomit shortly after taking Mekinist, do not take another dose. Take your next dose as scheduled
Follow all instructions for the oral suspension before preparing your first dose. Shake the oral suspension (liquid). Measure a dose with the supplied measuring device (not a kitchen spoon). The oral suspension can also be given through a feeding tube. Ask your doctor or pharmacist if you do not understand these instructions.
Doses are based on weight in children. Your child's dose may change if the child gains or loses weight.
You will need frequent medical tests to help determine if it is safe for you to keep receiving Mekinist. Your dose or medication schedule may be changed based on the results. Make sure to not miss any follow-up appointment.
Check your skin regularly during treatment and up to 6 months after taking Mekinist. Tell your doctor if you notice any new skin change such as redness, sores that will not heal, a new wart, or a mole that has changed in size or color.
Store the tablet in the refrigerator, do not freeze. Keep the medicine in the original container, along with the packet or canister of moisture-absorbing preservative. Do not store tablets in a pill box.
Store the mixed oral suspension at room temperature away from moisture and heat. Throw the oral suspension away after 35 days.
Warnings
Using Mekinist with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
Your healthcare provider should check your skin before you start treatment, and every two months while taking Mekinist to look for any new skin cancers.
Your healthcare provider may continue to check your skin for six months after you stop treatment.
What other drugs will affect Mekinist
Other drugs may interact with trametinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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