Melphalan oral/injection

Generic name: Melphalan (oral/injection)
Drug class: Alkylating agents

Usage of Melphalan oral/injection

Melphalan is used as a "palliative" treatment to relieve symptoms of multiple myeloma (a type of blood cancer) or a certain type of ovarian cancer.

Melphalan injection is used as a "conditioning" treatment for multiple myeloma before you receive a stem cell transplant.

Melphalan may also be used for purposes not listed in this medication guide.

Melphalan oral/injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin redness; blurred vision, feeling light-headed; fast heartbeats; trouble breathing; swelling of your face, lips, tongue, or throat.

Melphalan may cause serious side effects. Call your doctor at once if you have:

low white blood cell counts--fever, chills, cough, pain or burning when you urinate.

low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

easy bruising, unusual bleeding, purple or red spots under your skin;

sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;

severe ongoing nausea, vomiting, or diarrhea;

new or worsening cough, fever, trouble breathing;

unusual lumps or masses;

missed menstrual periods;

inflammation of your blood vessels--warmth or tingling, skin rash, fever, headache, body aches, night sweats, weight loss, feeling or weak or tired;

liver problems--loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects of melphalan may include:

low blood cell counts;

mouth sores;

tiredness;

low potassium levels; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Melphalan oral/injection

You should not use melphalan if you are allergic to it, or if you received melphalan in the past and it did not work.

Tell your doctor if you now have or have ever had:

nausea, vomiting, or diarrhea;

an infection or weak immune system (caused by disease or by using certain medicine);

liver or kidney disease; or

chemotherapy or radiation.

Using melphalan may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

Both men and women using this medicine should use effective birth control to prevent pregnancy during and shortly after treatment. Melphalan can harm an unborn baby or cause birth defects if the mother or father is using this medicine.

Ask your doctor how long you should keep using birth control after your last dose of melphalan. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using melphalan.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because melphalan can harm an unborn baby.

You should not breastfeed while using melphalan.

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How to use Melphalan oral/injection

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Melphalan oral is taken by mouth.

Melphalan injection is given as an infusion through a central intravenous (IV) line placed into a large vein. A healthcare provider will give you this injection. This medicine must be given slowly, and the infusion can take up to 30 minutes to complete. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when melphalan is injected.

As a palliative treatment for multiple myeloma: Melphalan injection is usually given every 2 to 4 weeks. Melphalan oral is usually taken daily and your doctor may occasionally ask you to stop taking it for a short time.

As a conditioning treatment stem cell transplant: Melphalan injection is usually given for 2 days in a row before stem cell transplant.

As a palliative treatment for ovarian cancer: Melphalan oral is usually taken for 5 days in a row every 4 to 5 weeks.

Follow your doctor's dosing instructions very carefully.

You may be given another medication to help prevent nausea. Keep using this medicine and tell your doctor if you have severe nausea, vomiting, or diarrhea.

Your blood will need to be tested often. This will help your doctor determine the correct dose for you. Your cancer treatments may be delayed based on the results of your blood tests.

You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

It may take several months before your body responds to melphalan. Your doctor will determine how long to treat you with this medicine. For best results, keep using melphalan as directed. You may not get the full benefit of this medicine if you stop using it too soon.

Store melphalan tablets in the refrigerator and protect them from light.

Warnings

While using melphalan, you may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, unusual bleeding or bruising, or pain or burning when you urinate.

What other drugs will affect Melphalan oral/injection

Other drugs may affect melphalan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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