Metformin and pioglitazone

Generic name: Metformin And Pioglitazone
Dosage form: oral tablet (500 mg-15 mg; 850 mg-15 mg)
Drug class: Antidiabetic combinations

Usage of Metformin and pioglitazone

Metformin and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels.

Metformin and pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections. Metformin and pioglitazone is not for treating type 1 diabetes.

Metformin and pioglitazone may also be used for purposes not listed in this medication guide.

Metformin and pioglitazone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some people using metformin and pioglitazone develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:

unusual muscle pain;

feeling cold;

trouble breathing;

feeling dizzy, light-headed, tired, or very weak;

stomach pain, vomiting; or

slow or irregular heart rate.

Metformin and pioglitazone may cause serious side effects. Call your doctor at once if you have:

pink or red urine, painful or difficult urination, new or worsening urge to urinate;

changes in your vision;

heart problems-- swelling, rapid weight gain, feeling short of breath;

liver problems--loss of appetite, nausea, vomiting, stomach pain, tiredness, dark urine, jaundice (yellowing of the skin or eyes); or

low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects of metformin and pioglitazone may include:

headache;

weight gain;

diarrhea; or

cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Metformin and pioglitazone

You should not use this medicine if you are allergic to metformin or pioglitazone, or if you have:

severe heart failure;

severe kidney disease;

active bladder cancer; or

metabolic acidosis or ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin and pioglitazone. Be sure your caregivers know ahead of time that you are using this medicine.

Tell your doctor if you have ever had:

kidney problems;

congestive heart failure or other heart problems;

fluid retention;

eye problems caused by diabetes;

bladder cancer;

a heart attack or stroke;

liver disease; or

if you are 80 years or older.

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Metformin and pioglitazone may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using metformin and pioglitazone. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Metformin and pioglitazone is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Metformin and pioglitazone

Usual Adult Dose for Diabetes Type 2:

Individualize dose based on safety, efficacy, and prior therapy-All doses provided as pioglitazone/metformin Immediate-release (IR): Initial dose: 15 mg/500 mg IR orally twice a day or 15 mg/850 mg IR orally once a day-For patients inadequately control on metformin monotherapy: May initiate with 15 mg/850 mg IR orally twice a day (depending on previous metformin dose)-For patients with NYHA Class I or Class II CHF: Initial dose: 15 mg/500 mg IR or 15 mg/850 mg IR orally once a dayMaintenance dose: Gradually titrate dose based on safety and efficacyMaximum dose: Pioglitazone 45 mg/Metformin 2550 mg per dayExtended-release (XR): Initial dose: 15 mg/1000 mg XR or 30 mg/1000 mg XR orally once a day-For patients inadequately control on pioglitazone or metformin monotherapy: 15 mg/1000 mg XR twice a day (depending on previous metformin dose) or 30 mg/1000 mg XR orally once a day Maintenance dose: Gradually titrate dose based on safety and efficacyMaximum dose: Pioglitazone 45 mg/Metformin 2000 mg per day Comments: -Initial doses for patients receiving combination therapy as separate tablets should be as close as possible to current regimen.-Take with meals and gradually titrate metformin doses to reduce gastrointestinal side effects; metformin doses above 2000 mg may be better tolerated given 3 times a day. -After initiation of therapy, and with each dose increase, carefully monitor for adverse reactions related to fluid retention.-If hypoglycemia occurs with concomitant use of insulin or insulin secretagogue, the insulin or insulin secretagogue dose should be reduced. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both pioglitazone and metformin is appropriate.

Warnings

You should not use metformin and pioglitazone if you have severe heart failure, severe kidney disease, active bladder cancer, metabolic acidosis, or ketoacidosis (call your doctor for treatment).

Metformin and pioglitazone can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin and pioglitazone.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

What other drugs will affect Metformin and pioglitazone

Many drugs can affect metformin and pioglitazone, making metformin and pioglitazone less effective or increasing your risk of lactic acidosis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

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