Methylprednisolone (Oral)

Generic name: Methylprednisolone
Drug class: Glucocorticoids

Usage of Methylprednisolone (Oral)

Methylprednisolone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Methylprednisolone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

This medicine is available only with your doctor's prescription.

Methylprednisolone (Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Black, tarry stools

blindness

bloating

bloody vomit

blurred vision

bone pain

change in vision

chest pain

chills

confusion

constipation

cough

dark urine

darkening of the skin

decrease in height

decrease in the amount of urine

decreased range of motion

decreased vision

diarrhea

difficulty in swallowing

dilated neck veins

dizziness or lightheadedness

dry mouth

extreme tiredness or weakness

eye pain

eye tearing

eyeballs bulge out of the eye sockets

fainting

feeling of constant movement of self or surroundings

fever

flushed, dry skin

fruit-like breath odor

full or bloated feeling

headache

heartburn

hives, itching, skin rash

impaired wound healing

increased hunger

increased thirst

increased urination

indigestion

irregular breathing

irregular heartbeat

joint pain

limp

loss of appetite

loss of consciousness

lower back or side pain

mental depression

mood changes

muscle pain, cramps, or weakness

nausea

nervousness

noisy, rattling breathing

numbness or tingling in the hands, feet, or lips

pain in the back, ribs, arms, or legs

pain or burning in the throat

pain or swelling in the arms or legs without any injury

painful or difficult urination

painful, swollen joints

pains in the stomach, side, or abdomen, possibly radiating to the back

pounding in the ears

pressure in the stomach

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

seizures

sensation of spinning

severe or continuing stomach pain

slow growth in children

slow or fast heartbeat

sores, ulcers, or white spots on the lips or tongue or inside the mouth

swelling of the face, fingers, feet, abdominal or stomach area, or lower legs

tearing

tightness in the chest

troubled breathing

troubled breathing at rest

unexplained weight loss

unusual tiredness or weakness

vomiting

vomiting of material that looks like coffee grounds

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Abnormal fat deposits on the face, neck, and trunk

acne

bruising

dry scalp

increased sweating

large, flat, blue or purplish patches in the skin

lightening of normal skin color

menstrual changes

reddish purple lines on the arms, face, legs, trunk, or groin

redness of the face

small, red or purple spots on the skin

swelling of the stomach area

thin, fragile skin

thinning of the scalp hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Methylprednisolone (Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of methylprednisolone in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of methylprednisolone in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Desmopressin

Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Aldesleukin

Amtolmetin Guacil

Aspirin

Atazanavir

Balofloxacin

Bemiparin

Besifloxacin

Bromfenac

Bufexamac

Bupropion

Celecoxib

Choline Salicylate

Ciprofloxacin

Clonixin

Cobicistat

Darunavir

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Dipyrone

Droxicam

Enoxacin

Etodolac

Etofenamate

Etoricoxib

Felbinac

Fenoprofen

Fepradinol

Feprazone

Fleroxacin

Floctafenine

Flufenamic Acid

Flumequine

Flurbiprofen

Gatifloxacin

Gemifloxacin

Ibuprofen

Indomethacin

Itraconazole

Ketoprofen

Ketorolac

Levofloxacin

Lomefloxacin

Lornoxicam

Loxoprofen

Lumiracoxib

Lutetium Lu 177 Dotatate

Macimorelin

Meclofenamate

Mefenamic Acid

Meloxicam

Morniflumate

Moxifloxacin

Nabumetone

Nadifloxacin

Nadroparin

Naproxen

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Nirmatrelvir

Norfloxacin

Ofloxacin

Oxaprozin

Oxyphenbutazone

Parecoxib

Pazufloxacin

Pefloxacin

Phenylbutazone

Piketoprofen

Piroxicam

Pranoprofen

Proglumetacin

Propyphenazone

Proquazone

Prulifloxacin

Ritonavir

Rofecoxib

Rufloxacin

Salicylic Acid

Salsalate

Sargramostim

Sodium Salicylate

Somatrogon-ghla

Sparfloxacin

Sulindac

Tacrolimus

Telaprevir

Tenoxicam

Tiaprofenic Acid

Tolfenamic Acid

Tolmetin

Tosufloxacin

Valdecoxib

Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol

Alcuronium

Aprepitant

Atracurium

Auranofin

Carbamazepine

Clarithromycin

Cyclosporine

Dalfopristin

Diltiazem

Erythromycin

Fluindione

Fosaprepitant

Gallamine

Hexafluorenium

Ketoconazole

Licorice

Metocurine

Mibefradil

Nefazodone

Phenobarbital

Primidone

Quinupristin

Rifampin

Saiboku-To

Troleandomycin

Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Relate drugs

How to use Methylprednisolone (Oral)

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects.

If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

Dose depends on medical condition:

Adults—At first, 4 to 48 milligrams (mg) per day. Your doctor may adjust your dose as needed.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to decide if you should continue to receive it. Blood or urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.

This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away.

Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

While you are being treated with methylprednisolone, do not have any immunizations (vaccines) without your doctor's approval. Methylprednisolone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.

This medicine may cause changes in mood or behavior for some patients. Tell your doctor right away if you have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while using this medicine.

This medicine might cause thinning of the bones (osteoporosis) or slow growth in children if used for a long time. Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is using this medicine, tell the doctor if you think your child is not growing properly.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain skin tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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