Metolazone

Generic name: Metolazone
Dosage form: oral tablet (10 mg; 2.5 mg; 5 mg)
Drug class: Thiazide diuretics

Usage of Metolazone

Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. Metolazone is also used to treat high blood pressure (hypertension).

Metolazone may also be used for purposes not listed in this medication guide.

Metolazone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Metolazone may cause serious side effects. Call your doctor at once if you have:

chest pain;

pounding heartbeats or fluttering in your chest;

easy bruising or bleeding;

a light-headed feeling, like you might pass out;

liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;

other signs of an electrolyte imbalance--dry mouth, nausea, vomiting, weakness, drowsiness, lack of energy, muscle pain, little or no urination, or feeling restless; or

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects of metolazone may include:

dizziness, spinning sensation;

drowsiness, tiredness;

depressed mood;

muscle or joint pain;

numbness or tingly feeling;

nausea, stomach pain, loss of appetite; or

diarrhea, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Metolazone

You should not use metolazone if you are allergic to it, or if you have:

severe liver disease; or

if you are unable to urinate.

To make sure metolazone is safe for you, tell your doctor if you have:

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

a heart rhythm disorder;

an allergy to sulfa drugs;

liver disease;

kidney disease;

diabetes;

gout; or

systemic lupus erythematosus.

Using metolazone during pregnancy could cause side effects in the newborn baby, such as blood cell problems, or jaundice (yellowing of the skin or eyes). Tell your doctor if you are pregnant or if you become pregnant while using metolazone.

Metolazone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Metolazone is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Metolazone

Usual Adult Dose for Hypertension:

Initial dose: 2.5 mg orally once a day (Zaroxolyn) or0.5 mg orally once a day (Mykrox).

Usual Adult Dose for Edema:

Initial dose: 5 mg orally once a day (Zaroxolyn) or0.5 mg orally once a day (Mykrox).

Warnings

You should not use metolazone if you are unable to urinate, or if you have severe liver disease.

What other drugs will affect Metolazone

Taking this medicine with other drugs that make you make you light-headed can worsen this effect. Ask your doctor before taking metolazone with a narcotic pain medicine, muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

any other blood pressure medication;

digoxin, digitalis;

furosemide or other diuretics (water pills);

insulin or oral diabetes medicine;

lithium;

methenamine;

vitamin D (at high doses);

a blood thinner--warfarin, Coumadin, Jantoven;

NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;

salicylates--aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others; or

steroid medicine--prednisone and others.

This list is not complete. Other drugs may interact with metolazone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

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