Metronidazole

Generic name: Metronidazole

Usage of Metronidazole

Metronidazole is an antibiotic that may be used to treat certain infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream.

Metronidazole has been approved to treat:

Symptomatic trichomoniasis (a sexually transmitted infection) in adults that has been confirmed by culture or wet smear test

Asymptomatic trichomoniasis in females when associated with cervical changes, and in asymptomatic sexual partners

Amebiasis (an infection caused by a parasite) in adults and children

Anaerobic bacterial infections (infections caused by bacteria that do not need oxygen to survive).

Metronidazole is thought to work by first diffusing into the cytoplasm of the anaerobic bacteria where it is then activated and reduced into a short-lived nitroso free radical which can interact with DNA, causing a loss of the helical DNA structure, strand breakage, and bacterial death.

Metronidazole is well absorbed after oral administration, with peak concentrations being reached in one to two hours. Although it starts to work quickly, it may take a couple of days before you start to feel better or notice an improvement in your symptoms. It is important that you still finish the course of metronidazole that your doctor has prescribed, even if you feel better, because the infection may still be present, and it could flare up or recur if you haven’t finished the course.

Metronidazole was first FDA-approved in 1963.

Metronidazole side effects

Get emergency medical help if you have signs of an allergic reaction to metronidazole (hives, itching, warmth, or tingling; fever, joint pain; dry mouth, dry vagina; stuffy nose, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Metronidazole may cause serious side effects including:

Nervous system problems, including brain disorder (encephalopathy), inflammation of the brain and spinal cord membranes (aseptic meningitis), numbness or tingling in the hands or feet (peripheral neuropathy), and seizures (convulsions). Tell your healthcare provider right away if you have any nervous system problems while taking metronidazole

Worsening yeast infection (candidiasis) symptoms in people with a known yeast infection or a yeast infection they were not aware of

Low white blood cell count (leukopenia) in people with a history of blood problems. This can affect how well the body fights infection.

The most common side effects of metronidazole include

Diarrhea

Nausea

Headache

Pain in the upper abdomen and abdominal cramping

Vomiting

Weight loss

Constipation.

Other side effects of metronidazole may include allergic reactions: such as itching, hives (urticaria), flushing of the skin, red skin rash that can be widespread, blisters and separation of skin layers, nasal congestion, dryness of the mouth and vagina, and fever.

Abnormal heart rhythms (QT prolongation) may also occur. Metronidazole can cause life-threatening liver problems in people with Cockayne syndrome. If you have this condition, stop taking this medicine and contact your doctor if you have signs of liver failure--nausea, stomach pain (upper right side), dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

These are not all the possible side effects of metronidazole. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Metronidazole

You should not use this medicine if you are allergic to metronidazole, secnidazole, or tinidazole, or if you:

drank alcohol in the past 3 days

consumed foods or medicines that contain propylene glycol in the past 3 days or

took disulfiram (Antabuse) within the past 14 days

have Cockayne Syndrome (a rare genetic disorder that affects growth and development).

Before taking metronidazole, tell your healthcare provider about all of your medical conditions, including if you:

liver disease

kidney disease (or if you are on dialysis)

a heart rhythm disorder

a stomach or intestinal disease such as Crohn's disease

a blood cell disorder such as anemia (lack of red blood cells) or low white blood cell (WBC) counts

medical problems that affect the brain or a nerve disorder

a yeast infection or a fungal infection anywhere in your body

a history of blood problems

or take any medications, especially warfarin, lithium, Busulfan, cimetidine, phenytoin, or phenobarbital.

Tell your doctor if you are pregnant or intend to become pregnant. The use of metronidazole during pregnancy has been well-studied and a review of 17 studies found that treating bacterial vaginosis and trichomoniasis with metronidazole reduced the risk of preterm birth and was effective and offered no teratogen risk. Conversely, isolated studies have suggested its use may result in low birth weight or preterm delivery. Talk to your doctor about the risks and benefits of taking metronidazole during pregnancy. Some product labels for metronidazole say it is contraindicated during the first trimester.

Tell your doctor if you are breastfeeding or plan to breastfeed. Metronidazole can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking metronidazole. If you are breastfeeding, you may consider pumping and throwing away your breast milk during treatment with metronidazole and for 48 hours after your last dose and feeding your infant stored human milk or formula.

Not all uses of metronidazole are approved for treating children and teenagers. Metronidazole is not approved to treat vaginal infections in girls who have not begun having menstrual periods.

How to use Metronidazole

Trichomoniasis (adults)

Treatment should be individualized. Usual dosages are:

One-day treatment: 2 grams as a single oral dose or a split dose given on the same day

7-day course: 250mg three times daily for 7 consecutive days.

Amebiasis

Adults: acute amebic dysentery. 750mg three times daily for 5 to 10 days.

Adults: amebic liver abscess. 500mg or 750mg three times daily for 5 to 10 days.

Children: 35mg/kg/24 hours to 50mg/kg/24 hours divided into three doses daily for 10 days.

Do not exceed adult dosages.

Anaerobic Bacterial Infections (adults)

For more serious anaerobic infections, intravenous metronidazole is usually administered initially.

Adults: 7.5 mg/kg every 6 hours (this works out at approximately 500mg for a 70kg adult) orally for 7 to 10 days. Maximum dose 4g/24 hours.

A longer course of treatment may be required for bone, joint, lower respiratory tract, and endocardium infections.

Warnings

To reduce the development of drug-resistant bacteria, do not use metronidazole to treat any condition that has not been checked by your doctor. This medicine will not treat a viral infection such as the common cold or flu.

Metronidazole has been shown to be carcinogenic in rats and mice and unnecessary use should be avoided.

Do not use metronidazole if you recently drank alcohol, or have taken disulfiram (Antabuse) within the past 2 weeks. Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking metronidazole and for at least 3 days after you stop taking it.

Seizures and other nervous system abnormalities have been reported in patients treated with metronidazole. You should stop using this medicine immediately if you experience any neurological symptoms such as seizures, headaches, visual changes, weakness, numbness, or tingling.

What other drugs will affect Metronidazole

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your current medicines. Many drugs can affect metronidazole, especially:

antidepressants, such as escitalopram

albuterol, an asthma medication

busulfan or other cancer medications

some heart or blood pressure medications

lithium or other antipsychotics

medicines to treat malaria, HIV, or other infections

blood thinners such as warfarin.

Drinking alcohol while taking metronidazole is not recommended because the combination can cause a reaction (often referred to as a disulfiram-like reaction) in some people. Symptoms may include flushing, headaches, nausea, vomiting, and stomach cramps. The product information and health professionals recommend not drinking alcohol or taking products that contain propylene glycol during metronidazole treatment and for 3 days after finishing the course.

This list is not complete and many other drugs may interact with metronidazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.

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