Miglitol

Generic name: Miglitol
Brand names: Glyset
Dosage form: oral tablet (100 mg; 25 mg; 50 mg)
Drug class: Alpha-glucosidase inhibitors

Usage of Miglitol

Miglitol delays the digestion of carbohydrates (forms of sugar) in your body. This decreases the amount of sugar that passes into your blood after a meal and prevents periods of hyperglycemia (high blood sugar).

Miglitol is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Miglitol may also be used for purposes not listed in this medication guide.

Miglitol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Miglitol may cause serious side effects. Call your doctor at once if you have:

severe diarrhea or constipation;

bloody or tarry stools;

rectal bleeding; or

diarrhea that contains blood or mucus.

Common side effects of miglitol may include:

stomach discomfort;

diarrhea;

gas; or

mild rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Miglitol

You should not use miglitol if you are allergic to it, or if you have:

an inflammatory bowel disease, ulcerative colitis, Crohn's disease;

a chronic intestinal disorder that affects your digestion;

blockage in your intestines;

a stomach disorder that causes excess gas; or

diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure miglitol is safe for you, tell your doctor if you have kidney disease.

Miglitol is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using miglitol.

Miglitol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medication to anyone under 18 years old without medical advice.

Relate drugs

How to use Miglitol

Usual Adult Dose for Diabetes Type 2:

Individualize dose based on efficacy and tolerability:Initial dose: 25 mg orally 3 times a day -After 4 to 8 weeks, may increase to 50 mg orally 3 times a day if needed; after 3 more months, may increase to 100 mg orally 3 times a day if needed based on glycosylated hemoglobin Maintenance dose: 50 mg to 100 mg orally 3 times a dayMaximum dose: 100 mg orally 3 times a dayComments:-Take orally at the start (with first bite) of each main meal; patients should be adhering to a diabetic diet to minimize GI side effects. -Some patients benefit from starting at 25 mg orally once a day with subsequent titration to 3 times a day to minimize GI side effects. -If no further reduction in postprandial glucose or HbA1c is observed with titration to 100 mg three times a day, consider lowering the dose. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Warnings

You should not use miglitol if you have inflammatory bowel disease (ulcerative colitis, Crohn's), a blockage in your intestines, a chronic intestinal disorder that affects digestion, or a stomach disorder that causes excess gas. Do not take miglitol if you are in a state of diabetic ketoacidosis.

What other drugs will affect Miglitol

Certain digestive-enzyme supplements may decrease the effects of miglitol and should not be taken at the same time, including:

pancreatin (amylase, protease, lipase); or

products such as Arco-Lase, Cotazym, Donnazyme, Pancrease, Creon, Ku-Zyme, and others.

You may be more likely to have low blood sugar if you take miglitol with other drugs that can lower blood sugar, including insulin or other oral diabetes medications.

Tell your doctor about all your current medicines and any you start or stop using, especially:

propranolol; or

ranitidine.

These lists are not complete and many other medicines can increase or decrease the effects of miglitol on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

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