Mimosa

Generic name: Albizia Julibrissin Durazz
Brand names: Mimosa, Persian Silk Tree, Pink Silk Tree, Powder-puff Tree, Shabkhosb, Silk Tree

Usage of Mimosa

In vitro studies document the anticancer activity of the various julibrosides against numerous cancer cell lines.(Cao 2007, Liang 2005, Tong 2003, Zheng 2006, Zheng 2010, Zou 2005, Zou 2000, Zou 2006, Zou 2004)

Antibacterial

The roots of mimosa inhibit the growth of streptomycetes.(Hartel 1992) Mimosa also inhibits the growth of oral streptococci.(Palombo 2011) Activity against Bacillus megaterium, Bacillus subtilis, Salmonella typhi, and Staphylococcus aureus has been documented.(Lv 2011)

Anti-inflammatory

A mimosa ethanol bark extract ranging from 5 to 20 mg/kg exhibited anti-inflammatory activity on ear edema in mice in a dose-dependent manner.(Qiao 2007)

Antioxidant

A dried methanolic stem bark extract displayed radical scavenging activity possibly attributable to its glycoside flavonoids.(Jung 2004, Lau 2007) An ethyl ether pod extract exhibited greater antioxidant activity compared with an extract made with petroleum ether.(Lv 2011) Mimosa foliage, flower, and whole-plant water extracts were tested for inhibition of low-density lipoprotein oxidation.(Vaughn 2007) The foliage water extracts possessed the highest inhibition, which was standardized at 2.5 mcM of flavonoids. Biomarkers of oxidative stress (ie, malonedialdehyde, catalase, protein carbonyl formation) were significantly improved with a methanolic extract of A. julibrissin flowers administered in an emesis animal model.(Ebrahimzadeh 2017)

Cancer

In vitro and animal data

Antitumor activity is associated with julibrosides J1, J2, and J3 against breast, prostate, and uterine cervical carcinoma cells.(Zheng 2006) Julibrosides J8 and J13 from an ethanol stem bark extract showed cytotoxic activity against hepatocarcinoma cells at 100 mcg/mL.(Zou 2005) Cytotoxic activity is also documented for julibroside J21 against hepatocarcinoma cells.(Zou 2006)

Julibrosides J1 and J9 from an ethanol stem bark extract showed cytotoxic activity against epidermoid carcinoma cell lines.(Zou 2000) Julibroside J28 showed antitumor activity against prostate, hepatocarcinoma, and uterine cervical carcinoma cells(Roy 2008); with inhibitory rates of 80.47%, 70.26%, and 58.53%.(Liang 2005)

Julibroside J8 also inhibited growth of a human gastric cancer cell line and may induce apoptosis in uterine cervical carcinoma cells through the caspase pathway, which is involved in programmed cell death.(Zheng 2006) Solid tumor growth was suppressed in mice treated with julibroside J8. The rate of inhibition for 0.5, 1.5, and 3 mg/kg of julibroside J8 treatment was 16.7%, 35.2%, and 67.5%.(Hua 2009) The anticancer activity may involve inhibition of growth, migration, and tube formation in the human dermal microvascular endothelial cell line.(Hua 2009) Another study in mice documents anticancer activity of mimosa's polysaccharides on sarcoma 180 solid form cancer cells.(Moon 1985)

HaBC18, an active substance isolated from mimosa dried stem bark powder, induced apoptotic DNA fragmentation of human acute leukemia Jurkat T cells through mitochondria-dependent activation of the caspase cascade.(Won 2006)

CNS

Animal data

A study in rats pretreated with mimosa documented anxiolytic-like effects potentially mediated by changes in the serotonergic nervous system, especially 5-hydroxytryptamine 1A receptors.(Jung 2005, Samwald 2010) Another study in chronically stressed rats found that mimosa alleviated growth inhibition caused by stress and regulated levels of monoamine brain neurotransmitters.(Zhand 2006) Meanwhile, in a sleep-deprived memory loss model, pre-treatment with mimosa (A. julibrissin) extract improved 3-hour memory impairment without affecting learning and memory in the non-sleep deprived group.(Chang 2019)

Antiemetic effects of mimosa have been observed in an emesis-induced animal model with administration of a methanolic extract of A. julibrissin flowers (total flavonoid content of quercetin equivalent 113 mg/g of extract). Significant reductions in emesis occurred at 50-, 100-, and 200-mg/kg doses of mimosa (P<0.001 for each) with up to a 60% and 69% reduction in retching caused by ipecac and copper sulfate, respectively, also observed.(Ebrahimzadeh 2017)

Clinical data

Mimosa is often marketed for relieving anxiety, depression, and stress. A pharmacoepidemiologic study in 2002 found that mimosa was the third most commonly prescribed Chinese herbal medicine for treating insomnia.(Chen 2011)

Diabetes and metabolic syndrome

In vitro data

Compounds extracted from A. julibrissin were found to have high insulin secretion stimulator properties in vitro without significantly affected cell viability.(Hager 2021)

Hepatoprotectant

In vitro data

Compounds extracted from A. julibrissin bark (also known as Albiziae cortex extract) significantly reversed free fatty acid-induced lipogenesis in hepatocytes in vitro (P<0.05). High glucose-induced oxidative stress was also mitigated by 3 of the 5 compounds extracted.(Shi 2019)

Vaccine adjuvant

Animal and experimental data

In animal models, antigen-specific antibody titers to inactivated H9N2 avian influenza vaccine formed significantly faster and higher with the use of a purified mimosa saponin fraction compared to the commercial oil adjuvant. Significant responses were documented at 7, 10, and 14 days after a single vaccination dose (P<0.05, P<0.01, and P<0.001, respectively).(Sun 2020) Similarly, the addition of the purified mimosa saponin fraction as a vaccine adjuvant led to significant increases in antigen-specific antibody titers to the Newcastle disease virus-based recombinant influenza vaccine (P<0.01). Titers were measured 2 weeks after the booster shot, which was given 14 days after the initial vaccination.(Du 2020)

Mimosa side effects

Research reveals limited information regarding adverse reactions with the use of mimosa.

Before taking Mimosa

Information regarding safety and efficacy in pregnancy and lactation is lacking.

How to use Mimosa

The herb is available from commercial manufacturers, and the most common dosage forms are liquids and capsules. Manufacturers suggest 3 to 6 mL of 1:2 mimosa liquid extract daily or 1 capsule 3 times daily with meals. However, capsule formulations are proprietary herbal blends and available in several strengths. Powders, teas, and tinctures are also available.

Warnings

Clinical studies are limited.

What other drugs will affect Mimosa

Use caution in patients taking mimosa with anticancer, anti-inflammatory, antidepressant, and antibacterial medications because information on potential drug-herb interactions is limited.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords