Mio-Rel

Generic name: Orphenadrine
Drug class: Skeletal muscle relaxants

Usage of Mio-Rel

Orphenadrine is used to help relax certain muscles in your body and relieve the stiffness, pain, and discomfort caused by strains, sprains, or other injury to your muscles. However, this medicine does not take the place of rest, exercise or physical therapy, or other treatment that your doctor may recommend for your medical problem .

Orphenadrine acts in the central nervous system (CNS) to produce its muscle relaxant effects .

This medicine is available only with your doctor's prescription .

Mio-Rel side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

  • Cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing

    • Incidence not known

  • Abdominal or stomach pain
  • diarrhea
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • glaucoma
  • joint or muscle pain
  • nausea
  • numbness or tingling of face, hands, or feet
  • redness and soreness of eyes
  • shortness of breath
  • sores in mouth
  • swelling of feet or lower legs
  • vomiting

    • Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of Overdose

  • Blurred vision
  • confusion, delirium, or hallucinations
  • constipation
  • difficult urination
  • drowsiness
  • dry eyes, mouth, nose, or throat
  • eye pain
  • flushing or redness of face
  • troubled breathing

    • Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Incidence not known

  • Anxiety
  • deep or fast breathing with dizziness
  • headache
  • irritability
  • itching skin
  • mental confusion
  • nervousness
  • numbness of feet, hands and around mouth
  • restlessness
  • trembling or shaking of hands or feet shakiness in legs, arms, hands, or feet
  • unusually large pupils of eyes
  • weakness

    • Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Before taking Mio-Rel

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Allergies

    The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

    Pediatric

    Appropriate studies have not been performed on the relationship of age to the effects of orphenadrine in the pediatric population. Safety and efficacy have not been established .

    Geriatric

    No information is available on the relationship of age to the effects of orphenadrine in geriatric patients. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require caution in patients receiving orphenadrine .

    Breast Feeding

    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Interactions with Medicines

    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Potassium Citrate

    • Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Alprazolam
  • Amantadine
  • Amifampridine
  • Benzhydrocodone
  • Bromazepam
  • Buprenorphine
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Cetirizine
  • Clobazam
  • Clonazepam
  • Clozapine
  • Codeine
  • Daridorexant
  • Dexmedetomidine
  • Dihydrocodeine
  • Donepezil
  • Doxylamine
  • Esketamine
  • Fentanyl
  • Flibanserin
  • Gabapentin
  • Gabapentin Enacarbil
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Hydrocodone
  • Hydromorphone
  • Ketamine
  • Lacosamide
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lofexidine
  • Loxapine
  • Magnesium Oxybate
  • Meperidine
  • Methacholine
  • Methadone
  • Metoclopramide
  • Midazolam
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Olanzapine
  • Oxycodone
  • Oxymorphone
  • Pentazocine
  • Phenobarbital
  • Potassium Oxybate
  • Pregabalin
  • Primidone
  • Quetiapine
  • Remifentanil
  • Remimazolam
  • Revefenacin
  • Ropeginterferon Alfa-2b-njft
  • Scopolamine
  • Secretin Human
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Tiotropium
  • Topiramate
  • Tramadol
  • Trazodone
  • Zolpidem
  • Zuranolone

    • Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Perphenazine

    • Interactions with Food/Tobacco/Alcohol

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

    Other Medical Problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Enlarged esophagus or
  • Enlarged prostate or
  • Glaucoma or
  • Intestinal blockage or
  • Myasthenia gravis or
  • Stomach ulcer or
  • Urinary tract blockage—Orphenadrine should not be used in patients with these conditions .
  • Heart problems (e.g., fast or irregular heartbeats, heart failure)—Use with caution. Orphenadrine may worsen these conditions .

    • Relate drugs

    How to use Mio-Rel

    A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins or into your muscle .

    Warnings

    Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor .

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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