Mitomycin

Generic name: Mitomycin
Brand names: Mutamycin
Dosage form: intravenous powder for injection (20 mg; 40 mg; 5 mg)
Drug class: Antibiotics / antineoplastics

Usage of Mitomycin

Mitomycin is used in combination with other cancer drugs to treat cancer of the stomach and pancreas.

Mitomycin may also be used for purposes not listed in this medication guide.

Mitomycin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mitomycin can damage red blood cells, which may cause irreversible kidney failure. Tell your doctor right away if you have unusual bruising or bleeding, pale skin, confusion, tiredness or irritability, stomach pain, bloody diarrhea, red or pink urine, swelling, rapid weight gain, and little or no urinating.

Mitomycin may cause serious side effects. Call your doctor at once if you have:

signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness);

wheezing, chest tightness, new or worsening cough, trouble breathing;

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or

pain, burning, redness, swelling, irritation, or skin changes where the injection was given.

Common side effects of mitomycin may include:

fever or other signs of infection;

nausea, vomiting, diarrhea, loss of appetite;

mouth sores;

drowsiness, headache;

blurred vision; or

temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Mitomycin

You should not be treated with mitomycin if you are allergic to it, or if you have:

low levels of platelets in your blood;

bone marrow suppression; or

active bleeding or any risk of bleeding.

Tell your doctor if you have ever had:

kidney disease;

heart disease; or

asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.

Mitomycin may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using mitomycin.

Relate drugs

How to use Mitomycin

Usual Adult Dose for Stomach Cancer:

After full hematologic recovery from any previous chemotherapy: 20 mg/m2 IV at 6- to 8-week intervalsComments:-Because of cumulative myelosuppression, patients should be reevaluated after each course of this drug and the dose reduced if the patient has experienced toxicity. -Doses greater than 20 mg/m2 have not been shown to be more effective and are more toxic than lower doses.Uses: -For disseminated adenocarcinoma of the stomach in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed-For disseminated adenocarcinoma of the pancreas in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed

Usual Adult Dose for Gastric Cancer:

Warnings

Mitomycin can also weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness).

What other drugs will affect Mitomycin

Other drugs may affect mitomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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