Mitomycin gel

Generic name: Mitomycin (gel)
Brand names: Jelmyto
Dosage form: ureteral kit (40 mg)
Drug class: Antibiotics / antineoplastics

Usage of Mitomycin gel

Mitomycin gel is used in adults to treat cancer of the lining of the upper urinary tract including the kidney.

Mitomycin gel may also be used for purposes not listed in this medication guide.

Mitomycin gel side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mitomycin gel may cause swelling and narrowing of your ureter (the tube that urine travels through from your kidney to your bladder). Call your doctor right away if you have a fever and pain in your side or lower back.

Also call your doctor at once if you have:

  • pain or difficult urination;
  • blood in your urine; or
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

    • Common side effects of mitomycin may include:

  • side pain, urination problems, blood in your urine;
  • kidney problems;
  • tiredness; or
  • nausea, vomiting, stomach pain.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Mitomycin gel

    You should not be treated with mitomycin if you are allergic to mitomycin gel, or if you have:

  • a perforation (a hole or tear) in your bladder or upper urinary tract.

    • You may need to have a negative pregnancy test before starting this treatment.

    Mitomycin gel can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, do not use mitomycin gel if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using mitomycin gel.

    • Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

    Relate drugs

    How to use Mitomycin gel

    Usual Adult Dose for Stomach Cancer:

    After full hematologic recovery from any previous chemotherapy: 20 mg/m2 IV at 6- to 8-week intervalsComments:-Because of cumulative myelosuppression, patients should be reevaluated after each course of this drug and the dose reduced if the patient has experienced toxicity. -Doses greater than 20 mg/m2 have not been shown to be more effective and are more toxic than lower doses.Uses: -For disseminated adenocarcinoma of the stomach in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed-For disseminated adenocarcinoma of the pancreas in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed

    Usual Adult Dose for Gastric Cancer:

    After full hematologic recovery from any previous chemotherapy: 20 mg/m2 IV at 6- to 8-week intervalsComments:-Because of cumulative myelosuppression, patients should be reevaluated after each course of this drug and the dose reduced if the patient has experienced toxicity. -Doses greater than 20 mg/m2 have not been shown to be more effective and are more toxic than lower doses.Uses: -For disseminated adenocarcinoma of the stomach in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed-For disseminated adenocarcinoma of the pancreas in proven combination with other approved chemotherapeutic agents or as palliative treatment when other modalities have failed

    Warnings

    Mitomycin gel may cause swelling and narrowing of your ureter (the tube that urine travels through from your kidney to your bladder). Call your doctor right away if you have a fever and pain in your side or lower back.

    What other drugs will affect Mitomycin gel

    Tell your doctor about all your other medicines, especially a diuretic or "water pill."

    Other drugs may affect mitomycin gel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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