Mogamulizumab

Generic name: Mogamulizumab
Brand names: Poteligeo
Dosage form: intravenous solution (kpkc 4 mg/mL)
Drug class: Miscellaneous antineoplastics

Usage of Mogamulizumab

Mogamulizumab is used to treat mycosis fungoides or Sézary syndrome in adults.

Mogamulizumab is given after at least one other medication did not work or has stopped working.

Mogamulizumab may also be used for purposes not listed in this medication guide.

Mogamulizumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, tired, itchy, hot or cold, or short of breath during the infusion.

Mogamulizumab may cause serious side effects. Call your doctor at once if you have:

  • a skin rash, itching, blistering or peeling;
  • painful mouth sores;
  • fever, chills, sore throat, cough;
  • nausea, diarrhea, stomach pain; or
  • shortness of breath.

    • Common side effects of mogamulizumab may include:

  • diarrhea;
  • rash;
  • feeling tired;
  • bone pain, muscle pain; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Mogamulizumab

    Tell your doctor if you have ever had:

  • a severe reaction after using mogamulizumab;
  • liver disease, including hepatitis B;
  • lung problems;
  • an autoimmune disorder; or
  • a stem-cell transplant from a donor.

    • You may need to have a negative pregnancy test before starting this treatment.

    Do not use mogamulizumab if you are pregnant. It could harm the unborn baby. Use effective birth control while you are using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

    It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

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    How to use Mogamulizumab

    Usual Adult Dose for Mycosis Fungoides:

    1 mg/kg IV over at least 60 minutes on days 1, 8, 15, and 22 of the first 28-day cycle, then on days 1 and 15 of each subsequent 28-day cycle until disease progression or unacceptable toxicityComments:-Administer premedication with diphenhydramine and acetaminophen for the first infusion.Uses: For relapsed or refractory mycosis fungoides (MF) or Sezary syndrome (SS) after at least one prior systemic therapy

    Warnings

    mogamulizumab can cause serious or life-threatening side effects.

    Call your doctor at once if you have a skin rash, itching, blistering or peeling, painful mouth sores, fever, chills, flu-like symptoms, trouble breathing, diarrhea, or stomach pain.

    Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, tired, itchy, hot or cold, or short of breath.

    What other drugs will affect Mogamulizumab

    Other drugs may affect mogamulizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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