Monopril

Generic name: Fosinopril
Dosage form: oral tablet (10 mg; 20 mg; 40 mg)
Drug class: Angiotensin Converting Enzyme Inhibitors

Usage of Monopril

Monopril is used alone or in combination with other medications to treat high blood pressure in adults and children at least 6 years old.

Monopril is also used in adults to treat congestive heart failure.

Monopril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors.

Monopril works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

Monopril side effects

Get emergency medical help if you have signs of an allergic reaction to Monopril: hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat.

Monopril may cause serious side effects. Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • kidney problems - swelling, urinating less, feeling tired or short of breath;
  • low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough;
  • high blood potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
  • liver problems - loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
  • Common Monopril side effects may include:

  • chest pain, cough, runny or stuffy nose;
  • muscle or joint pain, weakness;
  • nausea, vomiting, diarrhea; or
  • dizziness, low blood pressure.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Monopril

    You should not use Monopril if you are allergic to fosinopril or to any other ACE (angiotensin converting enzyme) inhibitor such as Captopril, Benazepril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.

    If you have diabetes, do not take Monopril together with any medication that contains aliskiren (a blood pressure medicine).

    Do not take Monopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto)

    To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • severe allergic reaction such as angioedema;
  • heart disease, heart problems such as a recent heart attack;
  • stomach pain;
  • low blood pressure;
  • if you are on a low-salt diet;
  • liver disease; or
  • kidney disease (or if you are on dialysis).
  • You may also need to avoid taking Monopril with aliskiren if you have kidney disease.

    Stop using this medicine and tell your doctor right away if you become pregnant. Fosinopril can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

    Do not breastfeed.

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    How to use Monopril

    Usual Adult Dose for Hypertension:

    Initial dose: 10 mg orally once a day alone or in combination with a diuretic Maintenance dose: 20 to 40 mg orally once a day; some patients may have further response at 80 mg once a day Comments: -Dosages should be adjusted according to blood pressure response at peak (2 to 6 hours post dose) and trough (about 24 hours after dosing) blood levels. -Consider dividing the daily dose in patients where the trough response is inadequate. -Stop the diuretic 2 to 3 days prior to beginning therapy with this drug; it may be resumed at a later time if clinically indicated. -If stopping the diuretic is not possible, careful medical supervision is recommended for several hours until blood pressure has stabilized. Uses: For the treatment of hypertension alone or in combination with other medications

    Usual Adult Dose for Congestive Heart Failure:

    Initial dose: 10 mg orally once a day Target dose range: 20 to 40 mg orally once a day Maximum dose: 40 mg orally once a day Comments: -Patients should be observed under medical supervision for at least 2 hours following the initial dose until blood pressure stabilizes. -Dosages should be increased over a several week period based on tolerability. -The presence of hypotension, orthostasis, or azotemia early in dose titration should not preclude further careful dose titration; consider dose reducing concomitant diuretic. Use: For the management of heart failure as adjunctive therapy when added to conventional therapy including diuretics with or without digitalis

    Usual Pediatric Dose for Hypertension:

    6 to 16 years: Greater than 50 kg: 5 to 10 mg orally once a day as monotherapy Less than 50 kg: Appropriate dose not available

    Warnings

    Do not use Monopril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

    If you have diabetes, do not use Monopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

    You may also need to avoid taking Monopril with aliskiren if you have kidney disease.

    What other drugs will affect Monopril

    Fosinopril can harm your kidneys, especially if you also use certain medicines for infections, cancer, or osteoporosis.

    Avoid taking an antacid within 2 hours before or after you take Monopril.

    Tell your doctor about all your other medicines, especially:

  • a diuretic or "water pill" that may increase blood potassium such as spironolactone, triamterene, amiloride;
  • medicine to prevent organ transplant rejection such as temsirolimus, sirolimus, or everolimus;
  • NSAIDs (nonsteroidal anti-inflammatory drugs<) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
  • heart or blood pressure medication.
  • This list is not complete. Other drugs may interact with fosinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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