Motixafortide

Generic name: Motixafortide
Drug class: Hematopoietic stem cell mobilizer

Usage of Motixafortide

Motixafortide injection is used in combination with a granulocyte-colony stimulating factor or G-CSF (eg, filgrastim) to mobilize hematopoietic stem cells (HSC) for collection and transplantation in patients with multiple myeloma (MM).

This medicine is to be given only by or under the direct supervision of your doctor.

Motixafortide side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

blurred vision

chest tightness

chills

confusion

cough

decreased urine

difficulty in breathing or swallowing

dizziness

dry mouth

eye pain

fast heartbeat

feeling of warmth

fever

general feeling of illness

headache

increased thirst

loss of appetite

mood changes

muscle pain or cramps

nausea or vomiting

nervousness

numbness or tingling in the hands, feet, or lips

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the face, neck, arms, and occasionally, upper chest

seizures

shakiness in the legs, arms, hands, or feet

skin itching, rash, or redness

sore throat

swelling of the face, throat, or tongue

trembling or shaking of the hands or feet

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

cracked, dry, scaly skin

ear swelling

swelling

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Motixafortide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of motixafortide injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of motixafortide injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

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How to use Motixafortide

A nurse or other trained health professional will give you this medicine in a medical facility. It is given as a shot under the skin of your upper arm, stomach, or thigh.

Your doctor will ask you to stay for 1 hour after receiving this medicine.

Your doctor will give you other medicines (eg, allergy medicine, stomach medicine, medicine for asthma, pain medicine) 30 to 60 minutes before receiving this medicine.

Your doctor will give you filgrastim once a day for 4 days before receiving this medicine.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control to keep from getting pregnant during treatment and for 8 days after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching skin, dizziness, lightheadedness, or fainting, feeling of warmth, redness of the face, neck, arms and occasionally, upper chest, nausea, swelling of the face, tongue, or throat, trouble breathing, chest pain, or vomiting after you receive the medicine.

This medicine may cause injection site reactions. Check with your doctor right away if you have bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.

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