Mounjaro

Generic name: Tirzepatide
Dosage form: injection, for subcutaneous use (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg,15 mg per 0.5 mL in single-dose pen)
Drug class: Incretin mimetics

Usage of Mounjaro

Mounjaro (tirzepatide) injection is used for type 2 diabetes in adults to lower blood sugar levels (blood glucose) and A1C levels. Mounjaro is a once-weekly injection that should be used with diet and exercise. Clinical trials for a 15 mg dose of Mounjaro (tirzepatide) for weight loss showed patients lost a mean of 20.9% of their body weight compared to 3.1% for placebo over 72 weeks. Zepbound is the name of the weight loss version of Mounjaro, they both contain the same active ingredient (tirzepatide), Mounjaro is FDA-approved for type 2 diabetes and Zepbound is FDA-approved to help with weight loss.

Mounjaro is the first GIP and GLP-1 receptor agonist, which works on the glucose-dependent insulinotropic polypeptide (GIP) receptors and the glucagon-like peptide-1 (GLP-1) receptors.

Mounjaro works to lower blood sugar by helping the pancreas make more insulin, lowering the amount of sugar your liver makes, and slowing the rate food passes through your body, making you feel full longer. It does this by activating the two receptors, GIP and GLP-1, which are natural incretin hormones that help regulate blood sugar levels.

Mounjaro injection became an FDA-approved medicine on May 13, 2022, to improve blood sugar (glucose) levels in adults with type 2 diabetes mellitus when used together with diet and exercise. Mounjaro is not for use in people with type 1 diabetes. It is not known if this medicine can be used in people who have had pancreatitis.

Mounjaro side effects

Common Mounjaro side effects

The most common Mounjaro side effects include nausea, diarrhea, decreased appetite, vomiting, constipation, dyspepsia, and abdominal pain, which affects 5% or more patients.

Serious Mounjaro side effects

Stop using this medicine and get emergency medical help if you have:

signs of an allergic reaction: hives; difficulty breathing; feeling light-headed; swelling of your face, lips, tongue, or throat; or

pancreatitis with symptoms of severe pain in your upper stomach spreading to your back, nausea and vomiting.

Call your doctor at once if you have:

severe stomach problems;

eye side effects or vision changes, including blurry vision or blurred vision;

signs of a thyroid tumor symptoms may include swelling or a lump in your neck, trouble swallowing, a hoarse voice, or if you feel short of breath;

gallbladder problem with symptoms including chalky-colored stools, stomach pain after eating, nausea, heartburn, bloating, and severe upper stomach pain that may spread to your back;

low blood sugar symptoms may include headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or

kidney problems with little or no urination, swelling in your feet or ankles, feeling tired or short of breath.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Mounjaro

You should not use this medicine if you:

are allergic to the tirzepatide or any ingredients contained in this medicine; see ingredients at the bottom of this page.

have a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or

multiple endocrine neoplasia type 2 (tumors in your glands).

Tell your doctor if you have ever had:

pancreas problems;

kidney disease;

a severe stomach problem such as problems with digesting food or slowed emptying of your stomach (gastroparesis); or

diabetic retinopathy (a diabetes complication that affects the eyes).

Pregnancy

Tell your healthcare provider if you are pregnant, you become pregnant, or plan to become pregnant while using this medicine. It is not known if this medicine will harm your unborn baby.

This medicine can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. If you take birth control pills, you may need to use additional birth control methods for 4 weeks after starting this medicine, and for 4 weeks each time, the dose is raised.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed while using this medicine. It is not known whether this tirzepatide passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using this medicine.

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How to use Mounjaro

Usual Adult Dose for Diabetes Type 2:

Initial dose: 2.5 mg under the skin (suBCutaneously) once a week.

After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week.

If additional glycemic control is needed: The dosage should be increased in 2.5 mg increments after at least 4 weeks on the current dose.

Maximum dose: 15 mg subcutaneously once a week.

Comments: The 2.5 mg dosage is for starting of treatment and is not intended for glycemic control. The day of weekly administration can be changed, if necessary, as long as the time between the 2 doses is at least 3 days (72 hours).

Warnings

Call your doctor immediately if you have thyroid tumor symptoms, such as a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

In studies with rats, tirzepatide and medicines that work in the same way caused thyroid tumors, including thyroid cancer. It is not known whether Mounjaro will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

You should not use this medicine if you or you have a family history of a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to this medicine.

What other drugs will affect Mounjaro

Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Birth control pills may not work as well while receiving this medicine. Your doctor may suggest you use another form of birth control for 4 weeks after starting this medicine and for 4 weeks after each dose change.

Taking tirzepatide with other medicines to treat diabetes like insulin or sulfonylureas may increase your risk of hypoglycemia. Talk to your doctor and pharmacist about low blood sugar and how to manage it.

This list is not complete. Many other drugs may interact with this medicine, including prescription and over-the-counter medicines, vitamins, and herbal products. To check for interactions with this medicine click the link below.

Disclaimer

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