Movantik

Generic name: Naloxegol
Drug class: Peripheral opioid receptor antagonists

Usage of Movantik

Movantik blocks certain effects of opioid medication. An opioid is sometimes called a narcotic.

Movantik reduces constipation caused by opioid pain medicine used to treat severe chronic pain. It works by treating constipation without reducing the pain-relieving effects of the opioid.

Movantik is used in people who have been taking opioid pain medicine for at least 4 weeks, to treat chronic pain that is not caused by cancer.

Movantik side effects

Get emergency medical help if you have signs of an allergic reaction to Movantik: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

symptoms of opioid withdrawal - anxiety, feeling irritable, sweating, chills, yawning, stomach pain, diarrhea.

Stop taking Movantik and call your doctor at once if you have:

severe stomach pain that will not go away; or

severe diarrhea.

Common Movantik side effects may include:

nausea, vomiting, stomach pain;

diarrhea, gas; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Movantik

You should not use Movantik if you are allergic to naloxegol, or if you have:

a blockage in your stomach or intestines.

Some medicines can cause unwanted or dangerous effects when used with naloxegol. Your doctor may need to change your treatment plan if you also use:

certain antibiotics;

imatinib;

isoniazid;

nefazodone;

an antibiotic - clarithromycin, telithromycin;

antifungal medicine - itraconazole, ketoconazole, posaconazole, voriconazole;

heart medication - nicardipine, quinidine; or

antiviral medicine to treat hepatitis C or HIV/AIDS - atazanavir, boceprevir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a stomach or intestinal disorder (including diverticulitis, or ischemic colitis);

stomach cancer, colorectal cancer;

a perforation (a hole or tear) in your esophagus, stomach, or intestines;

recent surgery on the stomach or intestines; or

liver or kidney disease.

If you use Movantik while you are pregnant, your baby could have opioid withdrawal symptoms. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while taking naloxegol.

Movantik is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Movantik

Usual Adult Dose for Constipation - Drug Induced:

Opioid-Induced Constipation - Chronic: Initial dose: 25 mg orally once a day Maintenance dose: 25 mg orally once a day; dose may be reduced to 12.5 mg orally once a day for patients unable to tolerate higher dose Comments: Prior to initiation, discontinue all maintenance laxative therapy; laxatives can be used as needed for suboptimal response after 3 days. Use: For the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain.

Warnings

You should not use Movantik if you have a blockage in your stomach or intestines.

Tell your doctor if you have symptoms of opioid withdrawal, such as anxiety, feeling irritable, sweating, chills, yawning, stomach pain, and diarrhea.

Stop using naloxegol and call your doctor at once if you have severe stomach pain and/or diarrhea (which can lead to serious medical problems).

Many drugs can interact with naloxegol, and some drugs should not be used together. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Movantik.

What other drugs will affect Movantik

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially bevacizumab.

This list is not complete. Other drugs may interact with naloxegol, including prescription ad over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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