Nadolol and bendroflumethiazide

Generic name: Nadolol And Bendroflumethiazide
Drug class: Beta blockers with thiazides

Usage of Nadolol and bendroflumethiazide

Nadolol and bendroflumethiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nadolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

Bendroflumethiazide is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

This medicine is available only with your doctor's prescription.

Nadolol and bendroflumethiazide side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain, tightness, or discomfort

confusion

cough

difficulty breathing

dilated neck veins

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

irregular breathing

lightheadedness, dizziness, or fainting

noisy breathing

paleness or cold feeling in fingertips and toes

slow or irregular heartbeat

slurred speech

sweating

swelling of face, fingers, feet, or lower legs

tingling or pain in fingers or toes when exposed to cold

unusual tiredness or weakness

weight gain

Incidence not known

Back or leg pains

black, tarry stools

bleeding gums

bloating

blood in urine or stools

chills

clay-colored stools

cloudy urine

cold sweats

constipation

coughing up blood

dark urine

difficulty swallowing

drowsiness

dry mouth

fast heartbeat

fever

flushed, dry skin

fruit-like breath odor

general body swelling

general feeling of discomfort or illness

general tiredness and weakness

headache

hives, skin rash

hoarseness

increased hunger

increased thirst

increased urination

indigestion

joint pain, stiffness, or swelling

light-colored stools

loss of appetite

lower back or side pain

muscle tremors

nausea and vomiting

nosebleeds

pain in the muscles

painful or difficult urination

pains in stomach, side, or abdomen, possibly radiating to the back

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid, deep breathing

redness, soreness, or itching skin

restlessness

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sores, welting, or blisters

stomach cramps

sugar in the urine

swollen or painful glands

tenderness of salivary glands

thickening of bronchial secretions

trouble breathing

unpleasant breath odor

unusual bleeding or bruising

unusual weight loss

upper right stomach pain

vomiting of blood

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness

decreased urination

diarrhea

fast, slow, or shallow breathing

gas

heartburn

increase in heart rate

increased sweating

indigestion

loss of consciousness

low blood pressure

muscle cramps

numbness, tingling, pain, or weakness in the hands or feet

pale or blue lips, fingernails, or skin

seizures

sunken eyes

trembling

unusual drowsiness, dullness, or feeling of sluggishness

unusual paleness

weakness and heaviness of the legs

wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Change in behavior

continuing ringing or buzzing or other unexplained noise in the ears

decreased interest in sexual intercourse

dry eyes or skin

excess air or gas in stomach or intestines

hair loss, thinning of hair

hearing loss

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

relaxed and calm

sleepiness

stomach soreness or discomfort

stuffy nose

weight loss

Incidence not known

Cracks in the skin

discoloration of skin

feeling of constant movement of self or surroundings

increased sensitivity of skin to sunlight

large, flat, blue or purplish patches in the skin

loss of heat from the body

muscle spasm, weakness, or restlessness

scaly skin

sensation of spinning

severe sunburn

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Nadolol and bendroflumethiazide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever HAD any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nadolol and bendroflumethiazide combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nadolol and bendroflumethiazide combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving nadolol and bendroflumethiazide combination.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

AceclofeNAC

Acemetacin

Acetyldigoxin

Albuterol

Amtolmetin Guacil

Arsenic Trioxide

Aspirin

Bepridil

Bromfenac

Bufexamac

Buprenorphine

Celecoxib

Ceritinib

Choline Salicylate

Clonidine

Clonixin

Codeine

Crizotinib

Darunavir

Deslanoside

Desmopressin

DexIbu-6998/">Ibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Digitalis

Digitoxin

Digoxin

Diltiazem

Dipyrone

Dofetilide

Dronedarone

Droperidol

Droxicam

Epinephrine

Etodolac

Etofenamate

Etoricoxib

Felbinac

Fenoldopam

Fenoprofen

Fepradinol

Feprazone

Fexinidazole

Fingolimod

Flecainide

Floctafenine

Flufenamic Acid

Flurbiprofen

Formoterol

Ibuprofen

Indacaterol

Indomethacin

Iobenguane I 131

Iohexol

Itraconazole

Ketanserin

Ketoprofen

Ketorolac

Lacosamide

Levalbuterol

Levomethadyl

Lidocaine

Lithium

Lornoxicam

Loxoprofen

Lumiracoxib

Meclofenamate

Mefenamic Acid

Meloxicam

Metildigoxin

Morniflumate

Nabumetone

Naproxen

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Olodaterol

Oxaprozin

Oxymetazoline

Oxyphenbutazone

Parecoxib

Phenylbutazone

Piketoprofen

Piroxicam

Ponesimod

Porfimer

Proglumetacin

Propyphenazone

Proquazone

Rivastigmine

Rofecoxib

Salicylic acid

Salmeterol

Salsalate

Siponimod

Sodium Salicylate

Sotalol

Sulindac

Tapentadol

Tenoxicam

Terbutaline

Tiaprofenic Acid

Tolfenamic Acid

Tolmetin

Valdecoxib

Verapamil

Vilanterol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetyldigoxin

Albiglutide

Alfuzosin

Alogliptin

Aminolevulinic Acid

Amtolmetin Guacil

Aspirin

Bromfenac

Bufexamac

Bunazosin

Canagliflozin

Celecoxib

Chlorpropamide

Choline Salicylate

Clonixin

Dapagliflozin

Deslanoside

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Digitoxin

Digoxin

Dipyrone

Doxazosin

Droxicam

Dulaglutide

Empagliflozin

Ertugliflozin

Etodolac

Etofenamate

Etoricoxib

Exenatide

Felbinac

Fenoprofen

Fepradinol

Feprazone

Floctafenine

Flufenamic Acid

Flurbiprofen

Ginkgo

Glimepiride

Glipizide

Glyburide

Gossypol

Ibuprofen

Indomethacin

Insulin Aspart, Recombinant

Insulin Degludec

Insulin Detemir

Insulin Glargine, Recombinant

Insulin Glulisine

Insulin Human Inhaled

Insulin Human Isophane (NPH)

Insulin Human Regular

Insulin Lispro, Recombinant

Ketoprofen

Ketorolac

Licorice

Linagliptin

Liraglutide

Lixisenatide

Lornoxicam

Loxoprofen

Lumiracoxib

Meclofenamate

Mefenamic Acid

Meloxicam

Metformin

Metildigoxin

Miglitol

Morniflumate

Moxisylyte

Nabumetone

Naproxen

Nateglinide

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Oxaprozin

Oxyphenbutazone

Parecoxib

Phenelzine

Phenoxybenzamine

Phentolamine

Phenylbutazone

Piketoprofen

Pioglitazone

Piroxicam

Pramlintide

Pranoprofen

Prazosin

Proglumetacin

Propyphenazone

Proquazone

Repaglinide

Rofecoxib

Rosiglitazone

Salicylic Acid

Salsalate

Saxagliptin

Sitagliptin

Sodium Salicylate

St John's Wort

Sulindac

Tamsulosin

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolfenamic Acid

Tolmetin

Trimazosin

Urapidil

Valdecoxib

Vildagliptin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Green Tea

Relate drugs

How to use Nadolol and bendroflumethiazide

This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the tablet whole. Do not crush, break, or chew it.

If you are also taking cholestyramine (Questran®) or colestipol (Colestid®), take Corzide® at least 1 hour before or 4 to 6 hours after these medicines.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral doSage form (tablets):

For high blood pressure:

Adults—At first, one tablet once a day. Your doctor may adjust your dose if needed.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause or worsen heart failure in some patients. Check with your doctor right away if you have chest pain or discomfort, dilated neck veins, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, weight gain, or unusual tiredness or weakness.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

Check with your doctor right away if you start having dry mouth, increased thirst, muscle cramps, nausea or vomiting, unusual tiredness or weakness, severe drowsiness or dizziness, seizures, a decrease in urine, or a fast heartbeat while you are using this medicine. These may be symptoms of dehydration or mineral imbalance.

Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

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