Nalmefene
Brand names: Revex
Drug class:
Antineoplastic Agents
Usage of Nalmefene
Postoperative Opiate Depression
Treatment of opiate-induced depression, including respiratory depression, caused by natural and synthetic opiates.
Opiate OverdoSage
Management of known or suspected opiate overdosage.
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How to use Nalmefene
Administration
Principally administered by IV injection; can be administered by IM or sub-Q injection if venous access cannot be established.
For reversal of postoperative opiate depression, administer blue-labeled commercially available injection containing 100 mcg/mL nalmefene.
For management of known or suspected opiate overdose, administer green-labeled commercially available injection containing 1 mg/mL nalmefene.
Proper steps should be taken to prevent use of incorrect concentration of injection.
IV Administration
Administer as an IV bolus.
DilutionWhen used for treatment of postoperative opiate-induced depression in patients with increased cardiovascular risk, it may be desirable to dilute to a final ratio of 1:1 in 0.9% sodium chloride injection or sterile water for injection. (See Cardiovascular Disease under Cautions.)
Dosage
Available as nalmefene hydrochloride; dosage expressed in terms of nalmefene.
Titrate dosage to reverse opiate-induced effects; when adequate opiate reversal has been established, additional doses of nalmefene are not required and may cause unwanted reversal of analgesia or precipitate withdrawal.
Adults
Postoperative Opiate Depression IVInitially, 0.25 mcg/kg given at 2- to 5-minute intervals until the desired response is obtained.
Weight-based Initial Dosage in Postoperative Patients aPatient Weight
Initial Dosage (0.25 mcg/kg)
Volume of Nalmefene 100 mcg/mL Solution (Blue-label) to Administer
50 kg
12.5 mcg
0.125 mL
60 kg
15 mcg
0.15 mL
70 kg
17.5 mcg
0.175 mL
80 kg
20 mcg
0.2 mL
90 kg
22.5 mcg
0.225 mL
100 kg
25 mcg
0.25 mL
Cumulative total dosage >1 mcg/kg does not provide additional therapeutic effect.
Patients at increased cardiovascular risk: Initially, 0.1 mcg/kg given at 2- to 5- minute intervals until desired response is obtained.
Opiate Overdosage IVOpiate naive patients: Initially, 7.14 mcg/kg (0.5 mg/70 kg), followed by a second dose of 14.29 mcg/kg (1 mg/70 kg) 2–5 minutes later, if necessary.
If no response is observed after a total dose of 21.43 mcg/kg (1.5 mg/70 kg), additional doses are unlikely to provide therapeutic effect.
Patients suspected of opiate Dependency: Initially, 1.43 mcg/kg (100 mcg/70 kg). If no withdrawal is observed within 2 minutes, 7.14 mcg/kg (0.5 mg/70 kg), followed by 14.29 mcg/kg (1 mg/70 kg) 2–5 minutes later, if necessary; observe closely for withdrawal symptoms.
If recurrence of respiratory depression occurs, titrate dosage incrementally to response to avoid over-reversal.
Prescribing Limits
Adults
Postoperative Opiate Depression IVCumulative dosage >1 mcg/kg does not provide additional therapeutic effect.
Opiate Overdosage IVCumulative dosages ≥21.43 mcg/kg (1.5 mg/70 kg) unlikely to increase therapeutic response.
Special Populations
Hepatic Impairment
Decreased clearance; however, dosage adjustment not required.
Renal Impairment
Decreased clearance. Dosage adjustment not required, however, administer incremental doses slowly (e.g., over 60 seconds) to minimize hypertension and dizziness associated with rapid administration in such patients.
Geriatric Patients
Dosage adjustment not required.
Warnings
Contraindications
Warnings/Precautions
Warnings
Additional Resuscitative MeasuresWhen used in emergency settings, other resuscitative measures (e.g., maintenance of an adequate airway, artificial respiration, administration of oxygen, vasopressor agents) should be readily available and used first when necessary.
Respiratory DepressionRisk of recurrent respiratory depression in postoperative and overdose patients after initial response to nalmefene.
Carefully monitor patients who have responded to nalmefene since the duration of action of some opiates (e.g., metHADone and levo-alpha-acetylmethadol [LAAM]) may exceed that of nalmefene; monitor patients until there is no reasonable risk of recurrent respiratory depression.
General Precautions
Cardiovascular DiseaseSerious adverse cardiovascular effects (e.g., VT and VF, pulmonary edema, hypertension, hypotension, cardiovascular instability) reported in postoperative patients and in emergency department settings following administration of nalmefene; may be associated with excessive doses.
Use with caution in patients with preexisting cardiovascular disease or in those receiving potentially cardiotoxic drugs. Reduced dosage recommended in postoperative patients at high risk for cardiovascular complications. (See Adults under Dosage and Administration.)
Precipitation of WithdrawalPossible precipitation of acute withdrawal symptoms. Use with extreme caution in patients with known physical dependence on opiates or following surgery involving high doses of opiates.
Observe patients suspected of opiate dependency for symptoms of withdrawal following initial and subsequent nalmefene injections.
Incomplete Reversal of BuprenorphineIncomplete reversal of buprenorphine-induced analgesia reported in animal models; therefore, nalmefene may not completely reverse buprenorphine-induced respiratory depression.
SeizuresPossible risk of seizures.
Specific Populations
PregnancyCategory B.
LactationDistributed into milk in rats; not known whether distributed into human milk. Use caution.
Pediatric UseSafety and efficacy not established in children <18 years of age.
Safety and efficacy not established in neonates, however, nalmefene may be used in the resuscitation of neonates when benefits outweigh the risks.
Geriatric UseInsufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults. (See Special Populations under Pharmacokinetics.)
Select dosage with caution because of age-related decreases in hepatic, renal, and/or cardiac function and potential for concomitant disease and drug therapy.
Hepatic ImpairmentDecreased clearance; however, dosage adjustments not recommended because nalmefene is administered as an acute course of therapy.
Renal ImpairmentDecreased clearance; administer dosages slowly to minimize adverse effects. (See Renal Impairment under Dosage and Administration.)
Common Adverse Effects
Nausea, vomiting, tachycardia, hypertension.
What other drugs will affect Nalmefene
Specific Drugs
Drug
Interaction
Comments
Anesthetics, inhalational
No deleterious interactions observed when nalmefene was administered after inhalation anesthetics
Benzodiazepines
No deleterious interactions observed when nalmefene was administered after benzodiazepines
Flumazenil
Risk of seizures
Skeletal muscle relaxants
No deleterious interactions observed when nalmefene was administered after skeletal muscle relaxants
Skeletal muscle relaxant antagonists
No deleterious interactions observed when nalmefene was administered after skeletal muscle relaxant antagonists and general anesthesia
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