Naloxegol

Generic name: Naloxegol
Brand names: Movantik
Dosage form: oral tablet (12.5 mg; 25 mg)
Drug class: Peripheral opioid receptor antagonists

Usage of Naloxegol

Naloxegol reduces constipation caused by opioid pain medicine used to treat severe chronic pain. Naloxegol works by treating constipation without reducing the pain-relieving effects of the opioid.

Naloxegol is used in people who have been taking opioid pain medicine for at least 4 weeks, to treat chronic pain that is not caused by cancer.

Naloxegol may also be used for purposes not listed in this medication guide.

Naloxegol side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Naloxegol may cause serious side effects. Call your doctor at once if you have:

  • symptoms of opioid withdrawal--anxiety, feeling irritable, sweating, chills, yawning, stomach pain, diarrhea.

    • Stop taking naloxegol and call your doctor at once if you have:

  • severe stomach pain that will not go away; or
  • severe diarrhea.

    • Common side effects of naloxegol may include:

  • nausea, vomiting, stomach pain;
  • diarrhea, gas; or
  • headache.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Naloxegol

    You should not use naloxegol if you are allergic to it, or if you have:

  • a blockage in your stomach or intestines.

    • Some medicines can cause unwanted or dangerous effects when used with naloxegol. Your doctor may need to change your treatment plan if you also use:

  • certain antibiotics;
  • antifungal medicine;
  • heart medication; or
  • antiviral medicine to treat hepatitis C or HIV.

    • Tell your doctor if you have ever had:

  • stomach or intestinal problems (including diverticulitis, or ischemic colitis);
  • stomach cancer, colorectal cancer;
  • a perforation (a hole or tear) in your esophagus, stomach, or intestines;
  • recent surgery on the stomach or intestines; or
  • liver or kidney disease.

    • If you use naloxegol while you are pregnant, your baby could have opioid withdrawal symptoms. Tell your doctor if you are pregnant or plan to become pregnant.

    Do not breastfeed while taking naloxegol.

    Naloxegol is not approved for use by anyone younger than 18 years old.

    Relate drugs

    How to use Naloxegol

    Usual Adult Dose for Constipation - Drug Induced:

    Opioid-Induced Constipation - Chronic:Initial dose: 25 mg orally once a day Maintenance dose: 25 mg orally once a day; dose may be reduced to 12.5 mg orally once a day for patients unable to tolerate higher doseComments: Prior to initiation, discontinue all maintenance laxative therapy; laxatives can be used as needed for suboptimal response after 3 days.Use: For the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain.

    Warnings

    You should not use naloxegol if you have a blockage in your stomach or intestines.

    Tell your doctor if you have symptoms of opioid withdrawal, such as anxiety, feeling irritable, sweating, chills, yawning, stomach pain, and diarrhea.

    Stop using naloxegol and call your doctor at once if you have severe stomach pain and/or diarrhea (which can lead to serious medical problems).

    Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

    What other drugs will affect Naloxegol

    Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

    Tell your doctor about all your other medicines, especially Bevacizumab.

    This list is not complete. Other drugs may affect naloxegol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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