Narcan

Generic name: Naloxone
Dosage form: Nasal spray
Drug class: Antidotes

Usage of Narcan

Narcan (naloxone) nasal spray is an over-the-counter medicine used to treat an opioid overdose emergency, Narcan works by rapidly reversing the opioid's effects. Naran should be given as soon as possible when an opioid overdose is suspected, and then the patient should also receive emergency medical care immediately, even if they wake up.

Narcan nasal spray became FDA-approved on March 29, 2023, as an over-the-counter (OTC) medicine without the need for a prescription, however, it is unknown when the OTC Narcan nasal spray product will be available. Until the OTC nasal spray becomes available, the nasal spray with the prescription label will still be available from a pharmacist without a prescription from your doctor under state Naloxone Access Laws or alternate arrangements.

Narcan nasal spray can be used for adults and children for known or suspected opioid overdose if there are signs of slowed breathing, severe sleepiness, or the person is not able to respond (loss of consciousness).

Narcan works to block the opioid effect as it is an opioid antagonist as it competes for the opiate receptors in the brain and other areas of the body to help reverse the dangerous effects of the opioid so that the patient's breathing improves and they become more awake, and their blood pressure normalizes.

Examples of opioids are codeine, oxycodone (Oxycontin), heroin morphine, hydrocodone (Vicodin, Lortab), Fentanyl, methadone, oxymorphone, Meperidine, tramadol, Buprenorphine, and hydromorphone.

Narcan was originally available as an njection, which has since been discontinued. The Narcan nasal spray is available as an over-the-counter medicine, so a prescription is NOT needed.

Narcan side effects

Get emergency medical help if you have signs of an allergic Reaction to Narcan: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Because Narcan reverses opioid effects, its use may cause sudden withdrawal symptoms such as:

nausea, vomiting, diarrhea, stomach pain;

fever, sweating, body aches, weakness;

tremors or shivering, fast heart rate, pounding heartbeats, increased blood pressure;

goose bumps, shivering;

runny nose, yawning; or

feeling nervous, restless, or irritable.

Sudden withdrawal symptoms in a baby younger than 4 weeks old may be life-threatening if not treated the right way. Symptoms include crying, stiffness, overactive reflexes, and seizures. Call your doctor or get emergency medical help if you are not sure how to properly give this medicine to a baby.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Narcan

You should not be treated with Narcan if you are allergic to naloxone or any of the ingredients in this nasal spray. Click here for a full list of Narcan ingredients

If possible before you receive Narcan, tell your doctor if:

you have heart problems; or

you are pregnant or breastfeeding.

If you use opioid medicine during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Using Narcan while you are pregnant may also cause opioid withdrawal effects in your unborn baby. However, having an opioid overdose can be fatal to both mother and baby. It is much more important to treat an overdose in the mother. You must get emergency medical help after using this medicine. Be sure all emergency medical caregivers know that you are pregnant.

If you use opioid medicine while you are pregnant, your baby could become Dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

In an emergency, you may not be able to tell caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you received Narcan.

Relate drugs

How to use Narcan

Usual Adult and Pediatric Dose for Opioid Overdose:

Administer 1 spray intranasally into 1 nostril

If desired response is not achieved after 2 or 3 minutes, give a second dose from a new nasal spray device, intranasally into alternate nostrils; additional doses may be administered every 2 to 3 minutes in alternating nostrils until emergency medical assistance arrives.

Comments:

IV route is recommended in emergency situations since it has the most rapid onset of action.

The duration of action of some opioids exceed that of this drug, therefore, repeat doses may be needed; the need for repeat doses will depend on the amount, type, and route of administration of the opioid being antagonized.

Patients should remain under continued surveillance; if a patients responds and relapses back into respiratory depression, additional doses should be given.

Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.

Warnings

Narcan is used to reverse the effects of opioid medicines temporarily, it will have no effect in people who are not taking opioid medicines. Always carry a nasal spray with you in case of an opioid overdose emergency.

Use Narcan as soon as possible if you or your caregiver think there are signs or symptoms of an opioid emergency, even if you are not sure because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:

unusual sleepiness and you are not able to wake the person up with a loud voice or by rubbing firmly on the middle of their chest (sternum)

breathing problems including slow or shallow breathing in a person who is difficult to wake up or who looks like they are not breathing

the pupil (black circle in the center of the colored part of the eye) is very small, sometimes called "pinpoint pupils," in someone difficult to awaken.

You should know where the nasal spray is stored and how to give the nasal spray before an opioid emergency happens. This is important if you have family members, caregivers, or other people who are at risk of opioid overdose and may need to have Narcan administered in an opioid emergency.

After giving the first dose of this medicine, you need to get emergency medical help right away, even if the person wakes up. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help

The signs and symptoms of an opioid emergency can return after this medicine is given. If this happens, give another dose after 2 to 3 minutes using a new nasal spray device and watch the person closely until emergency help is received.

What other drugs will affect Narcan

Other drugs may interact with naloxone, including prescription and over-the-counter medicines, vitamins, recreational drugs and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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