Nerlynx
Generic name: Neratinib
Usage of Nerlynx
Nerlynx is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Nerlynx is used alone or with other medicines to treat early-stage HER2-positive breast cancer. Nerlynx is also used to treat HER2-positive breast cancer that is advanced or has spread to other parts of the body (metastatic).
Nerlynx is used for breast cancer only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.
Nerlynx is usually given after you have been treated with another medicine called trastuzumab (Herceptin).
Nerlynx side effects
Get emergency medical help if you have signs of an allergic reaction to Nerlynx: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Nerlynx side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Nerlynx
To make sure Nerlynx is safe for you, tell your doctor if you have ever had:
You may need to have a negative pregnancy test before starting this treatment.
Neratinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
Do not breastfeed while using this medicine, and for at least 1 month after your last dose.
How to use Nerlynx
Usual Adult Dose for Breast Cancer -- Adjuvant:
240 mg orally once a day continuously for 1 year NOTE: Antidiarrheal prophylaxis is recommended during the first 2 cycles (56 days) of therapy and should be initiated with the first dose. Titrate loperamide to 1 to 2 bowel movements per day. MANUFACTURER SUGGESTED PROPHYLACTIC LOPERAMIDE DOSING: -Weeks 1 and 2 (days 1 through 14): 4 mg orally 3 times a day -Weeks 3 through 8 (days 15 through 56): 4 mg orally 2 times a day -Weeks 9 through 52 (days 57 through 365): 4 mg as needed (not to exceed 16 mg per day) Use: For the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer (to follow adjuvant trastuzumab-based therapy)
Warnings
Nerlynx can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be given anti-diarrhea medications for the first 2 months of treatment with Nerlynx.
Call your doctor if you are sick with severe diarrhea, or you also have weakness, dizziness, or a fever.
What other drugs will affect Nerlynx
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
If you also take an antacid: Wait at least 3 hours after taking the antacid before you take Nerlynx.
If you also take a stomach acid reducer: Take your Nerlynx dose 2 hours before or 10 hours after you take the other medicine (this includes cimetidine, famotidine, nizatidine, ranitidine, Axid, Pepcid, Tagamet, Zantac, and others).
You should not use certain stomach acid reducers, such as esomeprazole, lansoprazole, omeprazole, pantoprazole Nexium, Prevacid, Prilosec, Protonix, and others.
Other drugs may interact with neratinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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