Nityr

Generic name: Nitisinone
Drug class: Miscellaneous metabolic agents

Usage of Nityr

Nityr is a hydroxyphenyl-pyruvate dioxygenase inhibitor.

Nityr is used to treat adult and children with a rare genetic condition called hereditary tyrosinemia type 1 (HT-1) along with with dietary restriction of tyrosine and phenylalanine. HT-1 is a metabolic disorder that occurs when the body does not produce enough of an enzyme that breaks down proteins from certain foods. This condition occurs most often in young babies.

Nityr works by preventing the body from breaking down an amino acid called tyrosine and by keeping other toxic substances from building up and causing harm to your liver or kidneys.

Nityr side effects

Get emergency medical help if you have signs of an allergic reaction to Nityr: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may result from not properly following your diet plan and consuming restricted foods or beverages.

Call your doctor at once if you have:

  • a sudden change in behavior, ability, or development (sitting up, crawling, walking, talking, etc);
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • nausea, diarrhea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • vision problems;
  • eye pain, redness or swelling, burning, white or yellow patches on your eyes; or
  • calluses, peeling, or hardened skin on the palms of your hands or the soles of your feet.
  • Common Nityr side effects may include:

  • vision changes, your eyes may be more sensitive to light;
  • eye pain, red or puffy eyes;
  • nosebleeds;
  • increased sensitivity of your eyes to light;
  • rash or itching;
  • dry or peeling skin; or
  • thinning hair.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Nityr

    Tell your doctor if you have any medical conditions affecting your eyes.

    Tell your doctor if you are pregnant or breastfeeding.

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    How to use Nityr

    Take Nityr exactly as directed. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

    Do not change your medication dose or schedule without your doctor's advice.

    You must avoid certain foods for your treatment to be effective. Follow the diet plan created for you by your doctor or nutrition counselor.

    High protein foods are high in tyrosine and phenylalanine (including artificial sweeteners such as aspartame, Equal, or Nutrasweet). Since babies and children need protein to grow and develop, special foods have been developed to replace the high protein foods.

    You may take Nityr tablets with or without food.

    People who have a problem swallowing Nityr tablets whole, including children, can take Nityr tablets mixed with water in an oral syringe or crushed and mixed with applesauce. Nityr tablets should not be mixed in any other liquid or food.

    Take Nityr within 24 hours of adding water to tablets in an oral syringe. Throw away any unused tablet and water mixture stored in the oral syringe after 24 hours of being mixed together.

    Take Nityr within 2 hours of adding crushed Nityr tablets to applesauce. Throw away any crushed tablet and applesauce mixture that has not been used within 2 hours.

    Keep Nityr tablets and Nityr that has been prepared in an oral syringe with water or in applesauce out of direct sunlight.

    You may need frequent blood tests. Your vision may also need to be checked.

    Store Nityr tablets at room temperature between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Keep the tablets in the container they were dispensed in and keep the container tightly closed.

    Warnings

    Call your doctor at once if you have vision problems, eye pain, eye redness or burning, easy bruising, unusual bleeding, itching, or jaundice (yellowing of the skin or eyes). Tell your doctor if your baby has a sudden change in behavior, ability, or development (sitting up, crawling, walking, talking, etc).

    What other drugs will affect Nityr

    Other drugs may interact with nitisinone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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