Nivolumab and relatlimab
Generic name: Nivolumab And Relatlimab
Brand names: Opdualag
Dosage form: intravenous solution (rmbw 240 mg-80 mg/20 mL)
Drug class:
Antineoplastic combinations
Usage of Nivolumab and relatlimab
Nivolumab and relatlimab is used to treat people 12 years or older who weigh at least 88 lbs (40 kg) with a type of skin cancer called melanoma that has spread or cannot be removed by surgery.
Nivolumab and relatlimab may also be used for purposes not listed in this medication guide.
Nivolumab and relatlimab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Nivolumab and relatlimab may cause serious side effects. Call your doctor at once if you have:
Common side effects of nivolumab and relatlimab may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Nivolumab and relatlimab
Tell your doctor if you have ever had:
May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using nivolumab and relatlimab and for at least 5 months after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using nivolumab and relatlimab, and for at least 5 months after your last dose.
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How to use Nivolumab and relatlimab
Usual Adult Dose for Malignant Melanoma:
Recommended dose: 480 mg nivolumab and 160 mg relatlimab intravenously every 4 weeksDuration of therapy: Until disease progression or unacceptable toxicity occursUse: For the treatment of patients with unresectable or metastatic melanoma
Usual Pediatric Dose for Malignant Melanoma:
Recommended dose: 480 mg nivolumab and 160 mg relatlimab intravenously every 4 weeks in pediatric patients 12 years of age or older who weigh at least 40 kgDuration of therapy: Until disease progression or unacceptable toxicity occursComments:-No dosage recommendation has been established for pediatric patients 12 years and older weighing less than 40 kg. Use: For the treatment of patients with unresectable or metastatic melanoma
Warnings
Call your doctor at once if you have: new or worsening cough, shortness of breath, diarrhea or more frequent bowel movements than usual, severe abdominal pain or tenderness, severe nausea or vomiting, pain on the right side of your stomach area.
Also call your doctor at once if you have: extreme tiredness, weight gain or loss, decrease in the amount of urine, blood in your urine, rash, itching, irregular heartbeat, new or worse chest pain, memory problems, changes in mood or behavior, severe muscle pain or weakness, bruising.
What other drugs will affect Nivolumab and relatlimab
Other drugs may affect nivolumab and relatlimab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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