Norethindrone

Generic name: Norethindrone
Dosage form: oral tablet (0.35 mg; 5 mg)

Usage of Norethindrone

Norethindrone is a form of progesterone, a female hormone important for regulating ovulation and menstruation.

Norethindrone is used for birth control (contraception) to prevent pregnancy.

Norethindrone is also used to treat menstrual disorders, endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance.

Not all brands of norethindrone are for the same uses. Some brands are for use only as contraception. Others are for use in treating endometriosis or vaginal bleeding disorders. Avoid medication errors by using only the brand, form, and strength your doctor prescribes.

Norethindrone may also be used for other purposes not listed in this medication guide.

Norethindrone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Norethindrone may cause serious side effects. Call your doctor at once if you have:

sudden vision loss, bulging eyes, or severe headache;

swelling, rapid weight gain;

unusual vaginal bleeding;

missed menstrual periods;

pelvic pain (especially on one side);

a breast lump;

a light-headed feeling, like you might pass out;

increased thirst, increased urination;

liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or

signs of a blood clot--sudden numbness or weakness, problems with vision or speech, chest pain, shortness of breath, swelling or redness in an arm or leg.

Common side effects of norethindrone may include:

irregular vaginal bleeding or spotting;

headache;

breast pain or swelling;

stomach pain, bloating, nausea, vomiting;

hair loss;

depressed mood, trouble sleeping;

weight gain; or

vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Norethindrone

You should not use norethindrone if you are allergic to it, or if you have:

unusual vaginal bleeding that has not been checked by a doctor;

liver disease or a liver tumor;

breast cancer; or

a history of blood clots in your brain, eyes, lungs, or legs.

Do not use norethindrone if you are pregnant or trying to become pregnant. Stop taking the medicine and tell your doctor right away if you become pregnant.

Ask your doctor about using this medicine while you are breast-feeding. In some cases, you should not take norethindrone if you are nursing.

Tell your doctor if you have ever had:

heart disease, high blood pressure;

liver disease;

depression;

migraine headaches;

diabetes;

high cholesterol or triglycerides;

uterine fibroid tumors;

epilepsy;

kidney disease;

asthma; or

if you smoke.

Do not give this medicine to a child without medical advice.

How to use Norethindrone

Usual Adult Dose for Abnormal Uterine Bleeding:

2.5 to 10 mg orally once a dayDuration of therapy: 5 to 10 daysComments:-This drug should be used when the endometrium is adequately primed with endogenous/exogenous estrogen.-Withdrawal bleeding typically occurs within 3 to 7 days of treatment discontinuation.Use: Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance without organic pathology (e.g., submucous fibroids, uterine cancer)

Usual Adult Dose for Amenorrhea:

Usual Adult Dose for Contraception:

0.35 mg orally once a dayComment:-This drug should be taken at the same time each day.Use: Prevention of pregnancy

Usual Adult Dose for Endometriosis:

Initial dose: 5 mg orally once a day for 2 weeks-Maximum dose: 15 mg/dayComments:-The dose should be increased by 2.5 mg/day every 2 weeks until 15 mg is reached.-Treatment may continue for 6 to 9 months OR until annoying breakthrough bleeding demands temporary termination.Uses: Treatment of endometriosis

Usual Pediatric Dose for Contraception:

Postpubertal adolescents (under 16 years): 0.35 mg orally once a dayComments:-This drug should be used after menarche occurs.-The dose should be taken at the same time each day.Use: Prevention of pregnancy

Warnings

You should not use norethindrone if you you have: undiagnosed vaginal bleeding, breast cancer, liver disease, or a liver tumor. You may not be able to take norethindrone if you have ever had a heart attack, a stroke, or blood clot.

Do not use if you are pregnant or trying to become pregnant.

In some cases, you should not take norethindrone if you are nursing.

What other drugs will affect Norethindrone

Some drugs can make norethindrone less effective, which may result in unintended pregnancy if you use norethindrone for contraception. Tell your doctor about all your other medicines, especially:

St. John's wort;

medicine to treat an infection (antibiotics or antifungal medicine);

medicine to treat tuberculosis;

medicine to treat HIV or AIDS; or

seizure medication.

This list is not complete. Other drugs may affect norethindrone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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