Oliceridine
Generic name: Oliceridine
Brand names: Olinvyk
Dosage form: intravenous solution (1 mg/mL)
Drug class:
Opioids (narcotic analgesics)
Usage of Oliceridine
Oliceridine is an opioid medicine that is used to treat severe pain when other treatments have not provided relief.
Oliceridine may also be used for purposes not listed in this medication guide.
Oliceridine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Oliceridine may cause serious side effects. Call your doctor at once if you have:
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.
Common side effects of oliceridine may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Oliceridine
You should not use oliceridine if you are allergic to it, or if you have:
In some people, oliceridine breaks down very slowly in the liver and reaches higher than normal levels in the body. This can cause dangerously slow breathing and may cause death. Tell your doctor if you've ever been told you are a "poor metabolizer."
Tell your doctor if you have ever had:
If you use opioid medicine while you are pregnant, your baby could become Dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Ask a doctor before using this medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.
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How to use Oliceridine
Usual Adult Dose for Pain:
Initial dose: 1.5 mg intravenouslySupplemental dose: 0.75 mg intravenously every hour as needed, starting 1 hour after initial doseMaximum single dose: 3 mgMaximum daily dose: 27 mgPatient Controlled Analgesia (PCA):Recommended demand dose: 0.35 mg with a 6-minute lock out; may consider a demand dose of 0.5 mgMaximum dose: 27 mg per dayComments:-Use the lowest effective dose for the shortest duration consistent with treatment goals.-Individualize dose based on pain severity, patient response and prior analgesic experience, and addiction, abuse, and misuse risk.-Use beyond 48 hours has not been studied in trials.-Onset of analgesia is expected within 2 to 5 minutes of initial dose.-An initial 1 mg dose of this drug is approximately equipotent to 5 mg morphine; as patients differ in their response to opioids, use this comparison only as a guide.Use: Management of acute pain severe enough to require an intravenous opioid analgesic and for whom other treatments are inadequate. Because of the risk of addiction, abuse, and misuse, even at recommended doses, reserve use for those in whom alternative treatments (e.g. non-opioid analgesics or opioid combination products):-Have not been tolerated or toleration is not expected-Have not provided adequate analgesia or adequate analgesia is not expected
Warnings
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Using oliceridine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
What other drugs will affect Oliceridine
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
This list is not complete. Other drugs may affect oliceridine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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