Olpruva

Generic name: Sodium Phenylbutyrate
Drug class: Urea cycle disorder agents

Usage of Olpruva

Olpruva is used in adults and children to treat urea cycle disorders.

Olpruva can be used with other medicines and may also include changes in diet.

Olpruva may also be used for purposes not listed in this medication guide.

Olpruva side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Olpruva may cause serious side effects. Call your doctor at once if you have:

nervous system problems-- sleepiness, tiredness, feeling light-headed, vomiting, nausea, headache, confusion;

low blood potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

heart problems--swelling, rapid weight gain, feeling short of breath; or

signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding.

Common side effects of Olpruva may include:

missed menstrual periods or changes in your menstrual periods;

loss of appetite;

change in body odor; or

unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Olpruva

Olpruva should not be used to treat immediate symptoms of an ammonia build-up.

Tell your doctor if you have:

heart problems;

high blood pressure;

diabetes or a history of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase deficiency (Olpruva oral pellet contains sucrose); or

liver or kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

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How to use Olpruva

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may need to follow a special diet. Follow all instructions of your doctor or dietitian. Learn about the foods you should eat or avoid.

Wear a medical alert tag or carry an ID card to let others know you have a urea cycle disorder.

Doses are based on weight. Your dose may change if you gain or lose weight.

Take Olpruva with food.

Shake the oral powder lightly before mixing it with food.

Measure the dose of sodium phenylbutyrate oral pellets with the supplied measuring device (not a kitchen spoon).

Swallow Olpruva oral pellets immediately with soft food, such as applesauce, or water, fruit juices, or protein-free infant formulas. Do not chew or mix into liquids.

Do not give or take Olpruva oral suspension and oral pellets through a gastrostomy or nasogastric tube

Your blood may need to be tested often.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Throw away any remaining oral pellets 45 days after first opening the bottle.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What other drugs will affect Olpruva

Tell your doctor about all your other medicines, especially:

steroids;

haloperidol;

valproic acid; or

probenecid.

This list is not complete. Other drugs may affect Olpruva, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.