Omacetaxine
Generic name: Omacetaxine
Brand names: Synribo
Dosage form: subcutaneous powder for injection (3.5 mg)
Drug class:
Miscellaneous antineoplastics
Usage of Omacetaxine
Omacetaxine is used to treat chronic myeloid leukemia (CML).
Omacetaxine is given after at least two other cancer treatments did not work or have stopped working.
Omacetaxine may also be used for purposes not listed in this medication guide.
Omacetaxine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Omacetaxine may cause serious side effects. Call your doctor at once if you have:
Common side effects of omacetaxine may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Omacetaxine
You should not use omacetaxine if you are allergic to it.
Tell your doctor if you have ever had:
Omacetaxine can harm an unborn baby or cause birth defects if the mother or the father is using omacetaxine.
This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because omacetaxine can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
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How to use Omacetaxine
Usual Adult Dose for Chronic Myelogenous Leukemia:
Induction dose: 1.25 mg/m2 suBCUTAneously twice daily for 14 consecutive days of a 28 day cycle.Maintenance dose: 1.25 mg/m2 subcutaneously twice daily for 7 consecutive days of a 28 day cycle.Use: Chronic or accelerated phase CML with resistance and/or intolerance to two or more tyrosine kinase inhibitors.Comments: There are no trials verifying an improvement in disease-related symptoms or increased survival with omacetaxine.
Warnings
Omacetaxine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, confusion, problems with vision or speech, or new signs of infection (fever, chills, tiredness, body aches, feeling short of breath).
What other drugs will affect Omacetaxine
Other drugs may affect omacetaxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
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