Onglyza

Generic name: Saxagliptin
Drug class: Dipeptidyl peptidase 4 inhibitors

Usage of Onglyza

Onglyza is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.

Onglyza is used together with diet and exercise to improve blood sugar control in adults with type 2 type 2 diabetes mellitus.

Onglyza is not for treating type 1 diabetes.

Onglyza is sometimes used in combination with other diabetes medications.

Onglyza side effects

Get emergency medical help if you have signs of an allergic reaction to Onglyza: hives, a purple or red skin rash that spreads and causes blistering and peeling; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Onglyza and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Call your doctor at once if you have:

severe or ongoing pain in your joints;

pain or burning when you urinate; or

heart problems - shortness of breath (even while lying down), feeling weak or tired, rapid weight gain, swelling (especially in your feet, legs, or midsection.

Common Onglyza side effects may include:

painful urination;

headache;

runny or stuffy nose, sore throat, cough; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Onglyza

You should not use Onglyza if you have ever had a severe allergic reaction to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment).

To make sure Onglyza is safe for you, tell your doctor if you have ever had:

kidney disease (or if you are on dialysis);

heart disease;

pancreatitis;

gallstones;

high triglycerides (a type of fat in the blood); or

alcoholism.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Onglyza is not approved for use by anyone younger than 18 years old.

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How to use Onglyza

Usual Adult Dose for Diabetes Type 2:

2.5 or 5 mg orally once a day, regardless of meals Coadministration with strong CYP450 3A4/5 inhibitors: 2.5 mg orally once a day Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in multiple clinical settings

Warnings

You should not use Onglyza if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Onglyza is not for treating type 1 diabetes.

Before you take this medicine, tell your doctor if you have kidney disease or if you are on dialysis.

Onglyza is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What other drugs will affect Onglyza

Other drugs may increase or decrease the effects of saxagliptin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

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