Onivyde

Generic name: Irinotecan Liposomal
Drug class: Miscellaneous antineoplastics

Usage of Onivyde

Onivyde is used to treat pancreatic cancer that has spread to other parts of the body (metastatic). This medicine is usually given in combination with other cancer medicines.

Onivyde may also be used for purposes not listed in this medication guide.

Onivyde side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Onivyde may cause serious side effects. Call your doctor at once if you have:

severe or ongoing vomiting or diarrhea;

black or bloody stools;

sores or white patches in or around your mouth;

new or worsening cough or shortness of breath;

dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;

low blood cell counts--fever, tiredness, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed; or

symptoms of sepsis--confusion, fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill.

Common side effects of Onivyde may include:

fever, mouth sores, or other signs of infection;

diarrhea;

nausea, vomiting, loss of appetite; or

feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Onivyde

You should not use this medicine if you are allergic to irinotecan.

Tell your doctor if you have ever had:

liver or kidney disease;

lung disease; or

an intestinal disorder or obstruction.

Onivyde can harm an unborn baby if the mother or the father is using this medicine.

If you are a woman, you may need to have a negative pregnancy test. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.

If you are a man, use condoms if your sex partner is able to get pregnant. Keep using condoms for at least 4 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Onivyde.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

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How to use Onivyde

Onivyde is given as an infusion into a vein. A healthcare provider will give you this injection.

Onivyde must be given slowly, and the infusion can take up to 90 minutes to complete.

Onivyde can cause severe diarrhea, which can be life-threatening if it leads to dehydration.

Your doctor may recommend keeping anti-diarrhea medicine on hand at all times (such as loperamide or Imodium). Take this medicine at the first sign of loose or frequent bowel movements. Do not take loperamide for longer than 2 full days without your doctor's advice.

Call your doctor whenever you have diarrhea during your treatment with Onivyde.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

Warnings

Onivyde can cause severe diarrhea, which can be life-threatening. Call your doctor whenever you have diarrhea during your treatment with Onivyde.

What other drugs will affect Onivyde

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect Onivyde. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.