Orserdu

Generic name: Elacestrant
Dosage form: tablets

Usage of Orserdu

Orserdu (elacestrant) tablets are used to treat advanced or metastatic breast cancer that is estrogen receptor-positive, HER2-negative, and also has an ESR1 mutation. It is used in postmenopausal women or adult men with breast cancer that has progressed after being treated with endocrine therapy.

Orserdu is from the class of drugs called a selective estrogen receptor downregulator (SERD).

Orserdu is a tablet that is taken once a day with food.

Orserdu side effects

Serious side effects of Orserdu include:

increased fat (lipid) blood levels (hypercholesterolemia)

increased triglyceride blood levels (hypertriglyceridemia)

High triglyceride and lipid levels in your blood can increase your risk of heart attack and stroke. Your healthcare provider will do blood tests to check these levels before starting treatment and during treatment.

The most common side effects of Orserdu includes:

muscle and joint pain

increased kidney function test

nausea

reduced appetite

increased cholesterol and triglyceride blood levels

diarrhea

headache

increased liver function tests

constipation

tiredness

stomach-area (abdominal) pain

reduced red blood cell counts

hot flush

vomiting

heartburn or indigestion

decreased sodium levels in your blood

reduced fertility in males and in females who are able to become pregnant.

Your doctor may change your dose, temporarily stop treatment, or you may have to completely stop your Orserdu treatment if you develop certain side effects.

This is not a complete list of side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088

Before taking Orserdu

Before taking Orserdu, tell your healthcare provider about all of your medical conditions, especially if you:

have liver problems

are pregnant or plan to become pregnant.

Pregnancy and Orserdu

Orserdu can harm your unborn baby.

Females who are able to become pregnant:

your doctor may ask you to do a pregnancy test before you start treatment with this medicine.

you should use effective birth control (contraception) during treatment with this medicine and for 1 week after the last dose.

tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Orserdu.

Males with female partners who are able to become pregnant:

You should use effective birth control (contraception) during treatment with this medicine and for 1 week after the last dose.

Orserdu may impair fertility in males, and females who are able to become pregnant. It is important to talk to your healthcare provider if this is an issue for you.

Breastfeeding or planning to breastfeed.

It is not known if Orserdu passes into your breast milk.

Do not breastfeed during treatment with Orserdu and for 1 week after the last dose.

How to use Orserdu

Orserdu is a tablet that is taken once a day, at about the same time each day.

Swallow the tablet whole, do NOT chew, crush or split the tablets before swallowing. Do not take any tablets that are broken, cracked, or that look damaged.

Take Orserdu with food as this may help reduce nausea and vomiting.

If you miss taking your tablet or vomit after taking a tablet, do not take another tablet on that day. Skip the dose and take your next dose the following day at your regularly scheduled time.

Take this medicine exactly as your healthcare provider tells you.

Do not change your dose or stop taking this medicine unless your healthcare provider tells you.

What other drugs will affect Orserdu

Orserdu may interact with prescription and over-the-counter medicines, vitamins, and herbal supplements. It is important to tell your healthcare provider if you take any of these products. Orserdu and other products may affect each other causing side effects or changing each other's effects. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine, or when your dose changes or you stop a medicine.

CYP3A4 inducer medicines decrease the effects of Orserdu.

This includes:

Rifampin (Rifadin) an antibiotic used to treat tuberculosis

Carbamazepine (Carbatrol, Tegretol) used to control certain types of seizures in people with epilepsy.

St. John’s wort, an herbal supplement.

CYP3A4 inhibitor medicines increases the effects of Orserdu.

This includes:

Ketoconazole (Nizoral) used to treat fungal infections

Itraconazole (Sporanox) used to treat fungal infections

Atazanavir (Reyataz) used to treat HIV

nefazodone used to treat depression.

Goldenseal (a herbal supplement) should not be taken with this medicine.

You should not drink grapefruit juice or eat grapefruit because it can increase the effects of Orserdu.

This list is not complete. Other drugs may interact with Orserdu, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this document.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.