Pacritinib

Generic name: Pacritinib
Brand names: Vonjo
Dosage form: oral capsule (100 mg)
Drug class: Multikinase inhibitors

Usage of Pacritinib

Pacritinib is used to treat myelofibrosis in adults.

Pacritinib may also be used for purposes not listed in this medication guide.

Pacritinib side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pacritinib may cause serious side effects. Call your doctor at once if you have:

  • bleeding, bruising, and fever;
  • severe or ongoing diarrhea;
  • dizziness, a light-headed feeling, like you might pass out;
  • signs of a stroke--sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, dizziness, coughing up blood;
  • signs of a blood clot deep in the body--pain, swelling, or warmth in one leg;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
  • signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding.

    • Common side effects of pacritinib may include:

  • swelling in ankles, legs, and feet;
  • nausea and vomiting; or
  • pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Pacritinib

    Some drugs should not be used with pacritinib. Your treatment plan may change if you also use:

  • Nefazodone;
  • St. John's wort;
  • an antibiotic--clarithromycin, rifabutin, rifampin, rifapentine, Telithromycin;
  • antifungal medicine--itraconazole, ketoconazole;
  • antiviral medicine for HIV or hepatitis C--Boceprevir, cobicistat, dasabuvir, Elvitegravir, Indinavir, lopinavir/ritonavir, Nelfinavir, ombitasvir, paritaprevir, Saquinavir, Telaprevir, tipranavir;
  • cancer medicine--apalUTAmide, Enzalutamide, mitotane;
  • seizure medicine--Carbamazepine, oxcarbazepine, phenytoin, primidone; or
  • steroid medicine--Dexamethasone, prednisone.

    • Tell your doctor if you have ever HAD:

  • liver or kidney disease;
  • any other cancers;
  • a blood clot, or stroke;
  • a heart attack, or other heart problem;
  • if you have an infection;
  • if you have diarrhea (or loose stools), nausea or vomiting;
  • if you smoke or were a smoker; or
  • if you have active bleeding, have had severe bleeding, or plan to have surgery.

    • It is not known if pacritinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

    It may be harder for you to get a woman pregnant while you are using pacritinib.

    Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

    Relate drugs

    How to use Pacritinib

    Usual Adult Dose for Myelofibrosis:

    200 mg orally 2 times a dayUse: Treatment of patients with intermediate or high-risk primary or secondary (post-polycythemia vera OR post-essential thrombocythemia) myelofibrosis (MF) with a platelet count less than 50 times 10(9)/L (50 x 10(9)/L)

    Warnings

    Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

    What other drugs will affect Pacritinib

    Sometimes it is not safe to use certain medicines at the SAMe time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

    Other drugs may affect pacritinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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