Palonosetron injection

Generic name: Palonosetron (injection)
Brand names: Aloxi
Dosage form: intravenous solution (0.25 mg/2 mL; 0.25 mg/5 mL)
Drug class: 5HT3 receptor antagonists

Usage of Palonosetron injection

Palonosetron is used in adults to prevent nausea and vomiting caused by surgery, or by receiving medicine to treat cancer (chemotherapy).

Palonosetron is used in children as young as 1 month old only to prevent nausea and vomiting caused by cancer medicine.

Palonosetron may also be used for purposes not listed in this medication guide.

Palonosetron injection side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of palonosetron may include:

nausea, vomiting;

constipation;

slow heartbeats; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Palonosetron injection

You should not be treated with palonosetron if you are allergic to it.

Tell your doctor if you have ever had an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron (Anzemet) or Ondansetron (Zofran).

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with palonosetron and cause a serious condition called serotonin syndrome.

Tell your doctor if you are pregnant or breast-feeding.

Relate drugs

How to use Palonosetron injection

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

0.25 mg via IV infusion over 30 seconds ONCE 30 minutes before the start of chemotherapyComments:-The infusion line should be flushed with normal saline prior to and after administration of this drug.-This drug should not be mixed with other drugs.Uses:-Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy-Prevention of acute nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy

Usual Adult Dose for Nausea/Vomiting -- Postoperative:

0.075 mg via IV injection over 10 seconds ONCE immediately before induction of anesthesiaComments:-Efficacy beyond 24 hours has not been determined.-Routine prophylaxis is not recommended in patients in whom there is little expectation of postoperative nausea/vomiting (PONV).-Use is recommended in situations where nausea/vomiting must be avoided in the postoperative period, even when the incidence of PONV is low.Use: Prevention of PONV for up to 24 hours following surgery

Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:

1 month to younger than 17 years: 20 mcg/kg via IV infusion over 15 seconds ONCE 30 minutes before the start of chemotherapy-Maximum dose: 1.5 mg17 years and older: 0.25 mg via IV infusion over 30 seconds ONCE 30 minutes before the start of chemotherapyComments:-The infusion line should be flushed with normal saline prior to and after administration of this drug.-This drug should not be mixed with other drugs.Uses:-Patients 1 month to younger than 17 years: Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy-Patients 17 years and older: Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy-Patients 17 years and older: Prevention of acute nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy

Warnings

Before you receive palonosetron, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.

What other drugs will affect Palonosetron injection

Many drugs can affect palonosetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.