Palovarotene
Generic name: Palovarotene
Brand names: Sohonos
Dosage form: oral capsule (1 mg; 1.5 mg; 10 mg; 2.5 mg; 5 mg)
Drug class:
Miscellaneous uncategorized agents
Usage of Palovarotene
Palovarotene is used to reduce the number of new heterotopic ossifications (bony formations in muscle and soft tissue) in adults and female children aged 8 years or older or male children aged 10 years or older with fibrodysplasia ossificans progressiva.
Palovarotene may also be used for purposes not listed in this medication guide.
Palovarotene side effects
Get emergency medical help if you have signs of an allergic Reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Palovarotene can affect growth in children. Tell your doctor if your child is not growing at a normal rate while taking palovarotene.
This medicine can cause serious side effects, including:
Your palovarotene treatments may be changed, delayed or permanently discontinued if you have certain side effects.
Common side effects of palovarotene may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Palovarotene
You should not take palovarotene if you are allergic to palovarotene or similar retinoids medicines such as tretinoin, isotretinoin, or alitretinoin.
People with depression or mental illness may have thoughts about suicide. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.
Tell your doctor if you have or have ever had:
You will need to take a pregnancy test before, during, and after treatment with palovarotene.
May cause birth defects. Do not use if you are pregnant. You must use effective birth control while taking palovarotene and for at least one month after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while taking this medicine, and for at least one month after your last dose.
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How to use Palovarotene
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take palovarotene with food at the SAMe time each day.
Doses are based on weight in children and teenagers at least 13 years old. Your child's dose may change if the child gains or loses weight.
If you cannot swallow a capsule whole, open it and mix the medicine onto a teaspoon (5 mL) of soft food such as low-fat yogurt, warm oatmeal, or applesauce. Swallow the mixture without chewing within 1 hour of opening the capsule.
You may be given other products to help with serious side effects or allergic reaction. Use these products exactly as directed on the label, or as prescribed by your doctor.
You may need frequent medical tests. You may also need frequent eye exams.
Do not share this medicine with another person, even if they have the same symptoms you have.
Store at room temperature away from moisture, heat, and light.
Warnings
Do not use if you are pregnant. Use effective birth control.
Palovarotene can affect growth in children. Tell your doctor if your child is not growing at a normal rate while taking this medicine.
What other drugs will affect Palovarotene
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect palovarotene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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