Pamidronate

Generic name: Pamidronate
Brand names: Aredia
Drug class: Bisphosphonates

Usage of Pamidronate

Pamidronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Pamidronate is used to treat Paget's disease of bone. Pamidronate is also used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy).

Pamidronate is also used to treat bone damage caused by certain types of cancer such as breast cancer or bone marrow cancer. Pamidronate does not treat the cancer itself.

Pamidronate may also be used for purposes not listed in this medication guide.

Pamidronate side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pamidronate may cause serious side effects. Call your doctor at once if you have:

  • high fever;
  • new or unusual pain in your thigh or hip;
  • a seizure;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
  • low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).
  • Common side effects of pamidronate may include:

  • fever, headache;
  • bone pain;
  • increased blood pressure;
  • nausea, vomiting;
  • low calcium or phosphate levels; or
  • pain, redness, swelling or a hard lump under your skin around the IV needle.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Pamidronate

    You should not use this medicine if you are allergic to Mannitol, or to any bisphosphonate (alendronate, etidronate, ibandronate, pamidronate, risedronate, tiludronate, or zoledronic acid).

    To make sure pamidronate is safe for you, tell your doctor if you have ever had:

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
  • kidney disease;
  • liver disease; or
  • a dental problem (you may need a dental exam before you receive pamidronate).
  • In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use pamidronate, the more likely you are to develop this condition.

    Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

    Pamidronate may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine. Tell your doctor if you become pregnant. You may also need to use birth control for several weeks after your last dose of pamidronate. This medicine can have long-lasting effects on your body.

    It is not known whether pamidronate passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pamidronate.

    Pamidronate is not approved for use by anyone younger than 18 years old.

    Relate drugs

    How to use Pamidronate

    Usual Adult Dose for Hypercalcemia of Malignancy:

    Moderate Hypercalcemia (corrected serum calcium of approximately 12 mg/dL to 13.5 mg/dL):-60 to 90 mg single intravenous infusion over 2 to 24 hoursSevere Hypercalcemia (corrected serum calcium greater than 13.5 mg/dL):-90 mg single intravenous infusion over 2 to 24 hoursRetreatment:-Patients who show complete or partial response initially may be retreated if serum calcium does not return to normal or remain normal after initial treatment.-A minimum of 7 days between treatments is recommended to allow for full response to the initial dose.-The dose and manner of retreatment is identical to that of the initial therapy.Use: Treatment of moderate or severe hypercalcemia associated with malignancy, with or without bone metastases

    Usual Adult Dose for Paget's Disease:

    Moderate to severe Paget's Disease of the Bone:-30 mg intravenous infusion every day, administered over 4 hours for 3 consecutive days, for a total dose of 90 mgComments: When clinically indicated, retreat patients at the dose of initial therapy.

    Usual Adult Dose for Osteolytic Bone Lesions of Multiple Myeloma:

    -90 mg intravenous infusion administered over 2 hours every 4 weeksDuration of therapy: 24 months of therapy demonstrated overall benefitsComments:-Patients with marked Bence-Jones proteinuria and dehydration should receive adequate hydration prior to infusion of this drug.-Limited information is available on the use of pamidronate disodium in multiple myeloma patients with a serum creatinine greater than or equal to 3 mg/dL.

    Usual Adult Dose for Osteolytic Bone Metastases of Breast Cancer:

    -90 mg intravenous infusion administered over 2 hours every 3 to 4 weeksDuration of therapy: 24 months of therapy demonstrated overall benefits

    Warnings

    Pamidronate may harm an unborn baby. Avoid getting pregnant while using pamidronate and tell your doctor if you become pregnant.

    Call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, little or no urination, or swelling in your lower legs.

    What other drugs will affect Pamidronate

    Pamidronate can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medication, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

    Other drugs may interact with pamidronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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