Pasque Flower

Generic name: Pulsatilla Patens (L.) Mill., Pulsatilla Pratensis L., Pulsatilla Vulgaris Mill.
Brand names: Easter Flower, Meadow Anemone, Pasque Flower, Pulsatilla, Wind Flower

Usage of Pasque Flower

Protoanemonin has been reported to have antibacterialBaer 1946, Carlson 1946, Holden 1974, Seegal 1945 antimalarialCarlson 1946 and antifungalMartin 1990, Misra 1980 activity, and has been found to be cytotoxic as well.Campbell 1979 These properties may be due to the ability of protoanemonin to alkylate reactive moieties on proteins and other biomolecules.

The saponins of pulsatilla species have been reported to have cytotoxicMimaki 1999 antifungal, molluscicidalEkabo 1996 and sucrase inhibitory properties.Zhang 2000 The lignan beta-peltatin, isolated from P. chinensis, was strongly cytotoxic.Mimaki 1999 Antibacterial properties were reported for pulsaquinone, the quinone isolated from P. koreana.Moon 2000

Animal data

In animals, protoanemonin and anemonin have a sedating effect, while anemonin was antipyreticMartin 1988 effects also seen in screening of the extract of P. alpina.Martin 1987 A uterotonic effect of the extract has also been documented.Farnsworth 1975

Paradoxically, protoanemonin is antimUTAgenic in the Ames test.Minakata 1983 Sheep and other animals have been killed by overgrazing on protoanemonin-containing plants, and abortions and teratogenic effects have been observed.American Botanical Council 1998

Pasque Flower side effects

Blistering of the skin is due to protoanemonin, which, since it is volatile and reactive, both evaporates or is converted to anemonin on drying of the plant.Hill 1951

Before taking Pasque Flower

Documented adverse effects. Avoid use. Uterine stimulant.Brinker 1998, Ernst 2002 A uterotonic effect of the extract has also been documented.Farnsworth 1975

Pulsatilla was identified as the most common herb used for malpresentation/breech labor induction by certified or licensed midwives in state-wide surveys conducted in California, Texas, and North Carolina.Dennehy 2010

How to use Pasque Flower

There is no recent evidence to support specific doses of pasque flower. The fresh plant is toxic; classical doses of the dried herb were from 0.1 to 0.4 g daily.

Warnings

Fresh plant material of pasque flower is extremely toxic and should not be ingested or applied to the skin. Paradoxically, protoanemonin is antimutagenic in the Ames test.Minakata 1983 Sheep and other animals have been killed by overgrazing on protoanemonin-containing plants, and abortions and teratogenic effects have been observed.American Botanical Council 1998

What other drugs will affect Pasque Flower

None well documented.

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