Patisiran
Generic name: Patisiran
Brand names: Onpattro
Dosage form: intravenous solution (2 mg/mL)
Drug class:
Miscellaneous metabolic agents
Usage of Patisiran
Patisiran is used to treat adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis (damage of multiple nerves throughout the body).
Patisiran may also be used for purposes not listed in this medication guide.
Patisiran side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Common side effects of patisiran may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Patisiran
Before using patisiran tell your doctor about all your medical conditions or allergies.
Patisiran may harm an unborn baby. Tell your doctor if you are pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of patisiran on the baby.
It may not be safe to breastfeed while using patisiran. Ask your doctor about any risk.
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How to use Patisiran
Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:
Recommended dose based on actual body weight:-Weight less than 100 kg: 0.3 mg/kg intravenously once every 3 weeks-Weight 100 kg or greater: 30 mg intravenously once every 3 weeks Infuse at an initial rate of approximately 1 mL/min for the first 15 minutes, then increase to approximately 3 mL/min over 80 minutes. PREMEDICATION: Administer on the day of infusion at least 60 minutes prior to the start of infusion: -Oral acetaminophen 500 mg-Intravenous Corticosteroid (e.g., Dexamethasone 10 mg or equivalent)-Intravenous H1 blocker (e.g., diphenhydramine 50 mg or equivalent) -Intravenous H2 blocker (e.g., ranitidine 50 mg or equivalent) Comments:-The duration of infusion may be extended in the event of an infusion-related reaction (IRR).-If intravenous premedications are not available or not tolerated, oral equivalents may be used.-If patients are tolerating the infusion, but experiencing adverse reactions to corticosteroid premedication, reduce corticosteroid in 2.5 mg increments to a minimum dexamethasone 5 mg intravenous dose or equivalent.-Some patients may require additional or higher doses of one or more premedications to reduce the risk of IRRs.Use: For the treatment of adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis.
Warnings
Follow all directions on your prescription label and read all medication guides or instruction sheets. Tell your doctor if you use other medicines or have other medical conditions or allergies.
What other drugs will affect Patisiran
Other drugs may affect patisiran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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