Pegaspargase
Generic name: Pegaspargase
Brand names: Oncaspar
Dosage form: injectable solution (750 intl units/mL)
Drug class:
Miscellaneous antineoplastics
Usage of Pegaspargase
Pegaspargase is used in combination with other medicines to treat acute lymphoblastic leukemia.
Pegaspargase is also used to treat allergic reactions to another cancer medicine called asparaginase.
Pegaspargase may also be used for purposes not listed in this medication guide.
Pegaspargase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Pegaspargase may cause serious side effects. Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of pegaspargase may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Pegaspargase
You should not use this medicine if you are allergic to pegaspargase or asparaginase, or if you have ever received asparaginase and it caused any of the following conditions:
Tell your doctor if you have ever had:
You may need to have a negative pregnancy test before starting this treatment.
Pegaspargase may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.
Pegaspargase can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using pegaspargase, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.
Do not breastfeed while using this medicine, and for at least 3 months after your last dose.
Relate drugs
- Abiraterone
- Abiraterone, micronized
- Adagrasib
- Adstiladrin
- Altretamine
- Amivantamab
- Amivantamab-vmjw
- Arsenic trioxide
- Asparaginase Erwinia chrysanthemi
- Asparaginase erwinia chrysanthemi recombinant-rywn
- Asparlas
- Axicabtagene ciloleucel
- Azacitidine
- Azacitidine (Injection)
- Azacitidine (Oral)
- Abecma
- Bacillus of calmette and guerin vaccine, live (Intradermal)
- Bacillus of calmette and guerin vaccine, live (Intravesical)
- BCG intravesical
- Belantamab mafodotin
- Belantamab mafodotin-blmf
- Belzutifan
- Besponsa
- Bexarotene
- Bexarotene (Oral)
- Blenrep
- Brexucabtagene autoleucel
- Breyanzi
- Calaspargase pegol
- Calaspargase pegol-mknl
- Camptosar
- Carvykti
- Ciltacabtagene autoleucel
- Danyelza
- Dinutuximab
- Elahere
- Elotuzumab
- Elzonris
- Empliciti
- Enasidenib
- Enfortumab vedotin
- Enfortumab vedotin-ejfv
- Erwinaze
- Hexalen
- Hycamtin (Topotecan Intravenous)
- Hycamtin (Topotecan Oral)
- Hycamtin oral/injection
- Idecabtagene vicleucel
- Idhifa
- Imlygic
- Inotuzumab ozogamicin
- Irinotecan
- Irinotecan liposomal
- Irinotecan liposome
- Ivosidenib
- Kimmtrak
- Krazati
- Kymriah
- Lartruvo
- Levamisole
- Lisocabtagene maraleucel
- Loncastuximab tesirine
- Loncastuximab tesirine-lpyl
- Lumakras
- Lumoxiti
- Lunsumio
- Lysodren
- Matulane
- Mirvetuximab soravtansine
- Mirvetuximab soravtansine-gynx
- Mitotane
- Mogamulizumab
- Mogamulizumab-kpkc
- Mosunetuzumab
- Mosunetuzumab-axgb
- Moxetumomab pasudotox
- Moxetumomab pasudotox-tdfk
- Nadofaragene firadenovec-vncg
- Naxitamab
- Naxitamab-gqgk
- Novaplus Irinotecan Hydrochloride
- Olaratumab
- Olutasidenib
- Omacetaxine
- Oncaspar
- Onivyde
- Onureg
- Padcev
- Pegaspargase
- Polatuzumab vedotin
- Polatuzumab vedotin-piiq
- Polivy
- Poteligeo
- Procarbazine
- Rezlidhia
- Rozanolixizumab-noli
- Rybrevant
- Rylaze
- Rystiggo
- Sacituzumab govitecan
- Sacituzumab govitecan-hziy
- Selinexor
- Sotorasib
- Synribo
- Tagraxofusp
- Tagraxofusp-erzs
- Talimogene laherparepvec
- Talquetamab
- Talquetamab-tgvs
- Talvey
- Targretin
- Targretin (Bexarotene Oral)
- Tazemetostat
- Tazverik
- Tebentafusp
- Tebentafusp-tebn
- Tecartus
- Teclistamab
- Teclistamab-cqyv
- Tecvayli
- Theracys
- Tibsovo
- Tice BCG
- Tice BCG Live (for intravesical use)
- Tisagenlecleucel
- Tisotumab vedotin
- Tisotumab vedotin-tftv
- Tivdak
- Topotecan (Intravenous)
- Topotecan (Oral)
- Topotecan oral/injection
- Tretinoin
- Tretinoin (Oral)
- Trisenox
- Trodelvy
- Unituxin
- Venclexta
- Venetoclax
- Verteporfin
- Vesanoid
- Vidaza
- Visudyne
- Welireg
- Xpovio
- Xpovio 40 mg once-weekly
- Xpovio 40 mg twice-weekly
- Xpovio 60 mg twice-weekly
- Xpovio 80 mg twice-weekly
- Yescarta
- Yonsa
- Yonsa (Abiraterone Oral)
- Yonsa (Abiraterone, micronized Oral)
- Zynlonta
- Zytiga
How to use Pegaspargase
Usual Adult Dose for Acute Lymphoblastic Leukemia:
18 to 21 years:2500 international units/m2 IM or IV no more frequently than every 14 days21 years and older: 2000 international units/m2 IM or IV no more frequently than every 14 daysComments:-Monitor patients at least weekly, with bilirubin, transaminases, glucose. and clinical examinations until recovery from the cycle of therapy.Use: Component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) and hypersensitivity to native forms of L-asparaginase
Usual Pediatric Dose for Acute Lymphoblastic Leukemia:
1 year and older:2500 international units/m2 IM or IV no more frequently than every 14 daysComments:-IM: Single injection site volume administered should be limited to 2 mL. If volume to be administered is greater than 2 mL, multiple injection sites should be used.-IV: Give over a period of 1 to 2 hours in 100 mL of sodium chloride or Dextrose injection 5%, through an infusion that is already running. -Monitor patients at least weekly, with bilirubin, transaminases, glucose. and clinical examinations until recovery from the cycle of therapy.Use: Component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) and hypersensitivity to native forms of L-asparaginase
Warnings
You should not use pegaspargase if you are allergic to pegaspargase or asparaginase, if you have ever received asparaginase and it caused pancreatitis, severe bleeding, or a blood clot.
What other drugs will affect Pegaspargase
Other drugs may affect pegaspargase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
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