Pemigatinib

Generic name: Pemigatinib
Brand names: Pemazyre
Dosage form: oral tablet (13.5 mg; 4.5 mg; 9 mg)
Drug class: Multikinase inhibitors

Usage of Pemigatinib

Pemigatinib is used in adults to treat bile duct cancer that has spread to other parts of the body (metastatic) or cannot be removed with surgery. Pemigatinib is usually given after your cancer has been treated with another medicine.

Pemigatinib is used only if your cancer has a specific genetic marker (an abnormal "FGFR2" gene). Your doctor will test you for this gene.

Pemigatinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to pemigatinib, but further studies are needed.

Pemigatinib may also be used for purposes not listed in this medication guide.

Pemigatinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pemigatinib may cause serious side effects. Call your doctor at once if you have:

eye problems--eye pain or redness, dry or puffy eyes, watery eyes, your eyes may be more sensitive to light;

vision changes--blurred vision, seeing black spots or "floaters," or seeing flashes of light; or

high phosphate levels in your blood--muscle cramps, numbness, tingly feeling around your mouth.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of pemigatinib may include:

high or low phosphate levels in your blood;

dry eyes;

stomach pain, nausea, vomiting, loss of appetite;

diarrhea, constipation;

mouth sores, dry mouth;

joint pain, back pain;

feeling tired;

problems with your fingernails or toenails;

dry skin, hair loss; or

changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Pemigatinib

Tell your doctor if you have ever had:

problems with your eyes;

vision problems; or

trouble swallowing pills.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using pemigatinib should use effective birth control to prevent pregnancy. Pemigatinib can harm an unborn baby or cause a miscarriage if the mother or father is using this medicine.

Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using pemigatinib.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Relate drugs

How to use Pemigatinib

Usual Adult Dose for Cholangiocarcinoma of biliary tract:

13.5 mg orally once daily for 14 consecutive days followed by 7 days off therapy, in 21-day cyclesDuration of therapy: Until disease progression or unacceptable toxicity occurs.Comments:-FGFR 2 fusion positivity status must be known prior to initiation of therapy. -Assessment for FGFR 2 fusion positivity in tumor specimen should be performed with an appropriate diagnostic test.-This indication is approved under accelerated approval based on overall response rate and duration of response.Use: For the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test

Usual Adult Dose for Lymphoma:

13.5 mg orally once dailyDuration of therapy: Until disease progression or unacceptable toxicity occurs.Comments:-FGFR 1 rearrangement positivity status must be known prior to the initiation of therapy.-Assessment for FGFR 1 rearrangement positivity in tumor specimen should be performed with an appropriate diagnostic test.Use: For the treatment of adults with relapsed or refractory myeloid/lymphoid neoplasms (MLNs) with fibroblast growth factor receptor 1 (FGFR1) rearrangement

Usual Adult Dose for Multiple Myeloma:

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Pemigatinib

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect pemigatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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