Pentobarbital
Brand names: Nembutal
Drug class:
Antineoplastic Agents
Usage of Pentobarbital
Insomnia
Short-term treatment of insomnia (i.e., ≤2 weeks duration); decreased effectiveness for sleep induction and maintenance after 2 weeks.
Has been used for routine sedation. However, barbiturates used infrequently for this indication since there are few clinical situations in which oral barbiturates provide a safety or efficacy advantage over nonbarbiturate sedatives/hypnotics.
Surgery and Preanesthesia
Preoperatively, to produce sedation and relieve anxiety.
Provide basal hypnosis for general, spinal, or regional anesthesia, or to facilitate intubation procedures.
Seizure Disorders
Alternate therapy to control status epilepticus or acute seizure episodes resulting from meningitis, poisons, eclampsia, alcohol withdrawal, tetanus, or chorea.
IV Diazepam generally considered drug of choice for termination of status epilepticus.
Drug Withdrawal
Withdrawal of barbiturate or nonbarbiturate hypnotics in physically dependent patients.
Agitated Behavior
Has been used to control acute episodes of agitated behavior in psychoses† [off-label]; however, little value in long-term management of psychoses.
Coma Induction
Has been used in high doses to induce coma in the management of cerebral ischemia† [off-label] and increased intracranial pressure† [off-label] associated with head trauma, stroke, Reye’s syndrome, cardiac arrest, asphyxiation, or drowning.
Has been used to ameliorate or prevent sequelae associated with cerebral ischemia during neurosurgical procedures† [off-label] that require long periods of cerebral hypoxia.
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How to use Pentobarbital
General
Insomnia
Administration
Administer by IM or slow IV injection.
IV Administration
For solution and drug compatibility information, see Compatibility under Stability.
Reserve IV administration for inducing anesthesia or emergency treatment of acute seizure episodes or acute episodes of agitated behavior in psychoses. (See Seizure Disordersand also Agitated Behavior under Uses.)
Usually administered in a concentration of 50 mg/mL.
Must be administered by slow IV injection and in fractional doses to allow for adequate time for pentobarbital to distribute into CNS. A time interval of ≥1 minute is required to determine the full effect of an IV dose.
Administer under close supervision and in a setting where vital signs can be monitored; BP, respiration, and cardiac function maintained; and equipment for resuscitation and artificial ventilation are readily available. (See Respiratory and Cardiovascular Effects under Cautions.)
Avoid intra-arterial and extravascular injection. (See Intra-arterial Injection under Cautions.)
Rate of AdministrationDo not exceed 50 mg/minute. (See Respiratory and Cardiovascular Effects under Cautions.)
IM Administration
Administer by deep IM injection into a large muscle.
Administer a maximum volume of 5 mL at any one site to avoid tissue irritation.
After administration of large hypnotic doses, observe patient closely for 20–30 minutes and monitor vital signs to ensure narcosis will not be excessive.
Dosage
Available as pentobarbital sodium; dosage expressed in terms of the salt.
IV dosage generally determined by patient’s reaction to slow administration of the drug.
A time interval of >1 minute required to determine the full effect of an IV dose.
Pediatric Patients
Insomnia IM2–6 mg/kg or 125 mg/m2 as a single dose (maximum 100 mg).
Surgery and Preanesthesia IMUsually, approximately 5 mg/kg.
IVInitially, usually 50 mg. If necessary, administer subsequent doses after >1 minute.
Seizure Disorders IVInitially, usually 50 mg. If necessary, administer subsequent doses after >1 minute.
Agitated Behavior† [off-label] IVInitially, usually 50 mg. If necessary, administer subsequent doses after >1 minute.
Adults
Insomnia IM150–200 mg as a single dose.
IVInitially, usually 100 mg for an adult weighing 70 kg. After >1 minute, if necessary, administer additional small doses up to a total of 200–500 mg.
Surgery and Preanesthesia IM150–200 mg as a single dose.
Seizures IVInitially, usually 100 mg. After >1 minute, if necessary, administer additional small doses up to a total of 200–500 mg.
Administer minimum dosage to avoid compounding the CNS and respiratory depression which may follow seizures. (See CNS Depression and also Respiratory and Cardiovascular Effects, under Cautions.)
Drug Withdrawal IMEstablish a stabilizing dose (generally adminstered at 6-hour intervals), then decrease the daily dose by no more than 100 mg per day. Severely dependent patients can usually be withdrawn from barbiturates in 14–21 days.
Agitated Behavior† IVInitially, usually 100 mg. After >1 minute, if necessary, administer additional small doses up to a total of 200–500 mg.
Prescribing Limits
Pediatric Patients
Insomnia IMMaximum 100 mg daily.
Adults
IVMaximum 200–500 mg.
Special Populations
Hepatic Impairment
Dosage reduction recommended.
Renal Impairment
Dosage reduction recommended.
Geriatric Patients
Dosage reduction recommended.
Debilitated Patients
Dosage reduction recommended.
Warnings
Contraindications
Warnings/Precautions
Warnings
Pain ReactionPotential for paradoxical excitement and/or euphoria, restlessness, or delirium in patients with severe pain. Barbiturates could mask important symptoms in patients with acute or chronic pain. Use with caution in such patients. Should not be used in the presence of uncontrolled pain.
Abuse PotentialPossible tolerance, psychological dependence, and physical dependence following prolonged administration.
Withdrawal EffectsAbrupt cessation after prolonged use in dependent individuals may result in withdrawal symptoms (e.g., delirium, convulsions) and potentially be fatal. Drug must be withdrawn gradually in patients receiving excessive dosages over extended periods of time.
CNS DepressionPerformance of activities requiring mental alertness or physical coordination may be impaired.
Concurrent use of other CNS depressants may potentiate CNS depression. (See Specific Drugs under Interactions.)
Respiratory and Cardiovascular EffectsPossible respiratory depression, apnea, laryngospasm, or vasodilation and hypotension, particularly if pentobarbital is administered IV too rapidly. Administer slowly; personnel and equipment should be readily available for administration of artificial respiration.
Fetal/Neonatal MorbidityMay cause fetal harm. If used during pregnancy or if patient becomes pregnant, apprise of potential fetal hazard.
Retrospective, case-controlled studies indicate an association between maternal ingestion of barbiturates and a higher than expected incidence of fetal abnormalities.
Based on animal data, repeated or prolonged use of general anesthetics and sedation drugs, including pentobarbital, during the third trimester of pregnancy may result in adverse neurodevelopmental effects in the fetus. (See Pediatric Use under Cautions and also see Advice to Patients.)
Barbiturates have caused postpartum hemorrhage and hemorrhagic disease in neonates; readily reversible with vitamin K therapy.
Possible withdrawal symptoms in neonates born to women who received barbiturates throughout the last trimester of pregnancy. Premature neonates are particularly susceptible to the depressant effects of barbiturates.
PorphyriaPotential exacerbation of acute intermittent porphyria or porphyria variegata. (See Contraindications under Cautions.)
Complex Sleep-related BehaviorsPotential risk of complex sleep-related behaviors such as sleep-driving (i.e., driving while not fully awake after ingesting a sedative-hypnotic drug, with no memory of the event), making phone calls, or preparing and eating food, while asleep.
Sensitivity Reactions
Potential risk of anaphylaxis and angioedema; may occur as early as with the first dose of drug.
Dermatologic Effects and Hypersensitivity ReactionsExfoliative dermatitis (e.g., Stevens-Johnson syndrome), sometimes fatal, reported rarely. Because skin eruptions can precede potentially fatal reactions, discontinue pentobarbital whenever dermatologic reactions occur.
General Precautions
Intra-arterial InjectionInadvertent intra-arterial administration can cause local reactions varying in severity from transient pain to gangrene. Inadvertent extravascular injection may cause local tissue damage and result in necrosis.
Discontinue injection if the patient complains of pain in limb.
SuicideUse with caution, if at all, in patients with depression or suicidal tendencies.
Concomitant DiseasesUse parenterally with caution in patients with hypertension, hypotension, pulmonary or cardiovascular disease, or shock.
Specific Populations
PregnancyCategory D. (See Fetal/Neonatal Morbidity under Cautions.)
LactationDistributed into milk; use with caution.
Pediatric UseRepeated or prolonged use of general anesthetics and sedation drugs, including pentobarbital, in children <3 years of age or during the third trimester of pregnancy may adversely affect neurodevelopment. In animals, use for >3 hours of anesthetic and sedation drugs that block N-methyl-d-aspartic acid (NMDA) receptors and/or potentiate GABA activity leads to widespread neuronal apoptosis in the brain and long-term deficits in cognition and behavior; clinical relevance to humans is unknown.
Some evidence suggests similar deficits may occur in children following repeated or prolonged exposure to anesthesia early in life. Some evidence also indicates that a single, relatively brief exposure to general anesthesia in generally healthy children is unlikely to cause clinically detectable deficits in global cognitive function or serious behavioral disorders. Most studies to date have substantial limitations; further research needed to fully characterize effects, particularly for prolonged or repeated exposures and in more vulnerable populations (e.g., less healthy children).
Consider benefits and potential risks when determining the timing of elective procedures requiring anesthesia. FDA states that medically necessary procedures should not be delayed or avoided. (See Advice to Patients.)
Geriatric UsePossible increased sensitivity to barbiturates. Geriatric patients may frequently react to barbiturates with excitement, confusion, or depression.
Debilitated PatientsPossible increased sensitivity to barbiturates. Debilitated patients may frequently react to barbiturates with excitement, confusion, or depression.
Hepatic ImpairmentUse with caution; should not be used in patients with marked hepatic impairment, including patients with premonitory signs of hepatic coma.
Common Adverse Effects
Residual sedation, drowsiness, lethargy, vertigo, nausea, vomiting, headache.
What other drugs will affect Pentobarbital
Metabolized by hepatic microsomal enzymes. Induces hepatic microsomal enzymes.
Specific Drugs
Drug
Interaction
Comments
Anticoagulants, oral (e.g., warfarin)
Possible decreased plasma warfarin concentrations
Adjust anticoagulant dosage as necessary, especially upon initiation or discontinuance of pentobarbital
CNS depressants (e.g., sedatives, hypnotics, antihistamines, tranquilizers, alcohol)
Possible additive depressant effects
Contraceptives, oral
Possible enhanced metabolism of estrogenic and progestinic components; potential for decreased oral contraceptive effectiveness and increased risk of pregnancy with pentobarbital pretreatment or concurrent therapy
Consider alternate methods of contraception
Corticosteroids
Possible increased corticosteroid metabolism
Dosage adjustment of corticosteroid may be required; closely monitor patients (especially asthmatics) receiving corticosteroids when pentobarbital is initiated
Doxycycline
Possible decreased half-life of doxycycline; effect may persist up to 2 weeks after discontinuance of pentobarbital
If possible, avoid concomitant administration; if administered concomitantly, monitor clinical response to doxycycline
Griseofulvin
Possible decreased griseofulvin absorption, resulting in decreased blood concentrations
Avoid concomitant administration; if concomitant therapy is necessary, administration of griseofulvin in 3 divided doses daily may improve absorption
Monitor blood griseofulvin concentrations and increase dosage, if necessary
MAO inhibitors
Possible prolongation of pentobarbital effects
Dose adjustment of pentobarbital may be required
Phenytoin
Increased, decreased, or no change in plasma phenytoin concentrations reported
Monitor plasma concentrations of phenytoin and pentobarbital; adjust dosages as necessary
Valproic acid
Possible increased plasma pentobarbital concentrations
Monitor plasma pentobarbital concentrations and adjust dosage as needed
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