Pentobarbital injection

Generic name: Pentobarbital (injection)
Dosage form: injectable solution (50 mg/mL)
Drug class: Barbiturates

Usage of Pentobarbital injection

Pentobarbital is used short-term to treat insomnia, or to cause you to fall asleep for surgery.

Pentobarbital is also used as an emergency treatment for seizures.

Pentobarbital may also be used for purposes not listed in this medication guide.

Pentobarbital injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pentobarbital may cause serious side effects. Call your doctor at once if you have:

confusion, agitation, hallucinations;

weak or shallow breathing;

slow heart rate, weak pulse; or

a light-headed feeling, like you might pass out.

Side effects such as confusion, depression, or excitement may be more likely in older adults and those who are ill or debilitated.

Common side effects of pentobarbital may include:

drowsiness, dizziness;

loss of balance or coordination;

nausea, vomiting, constipation;

overactive reflexes;

sleep problems (insomnia), nightmares; or

feeling restless or excited (especially in children or older adults).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Pentobarbital injection

You should not use pentobarbital if you are allergic to it, or if you have:

a history of porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Tell your doctor if you have ever had:

liver disease;

kidney disease;

temporary or chronic pain; or

an addiction to phenobarbital or similar medicines.

Pentobarbital may harm an unborn baby. If you use pentobarbital during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Phenobarbital can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Sedatives used during surgery may affect brain development in a young child or unborn baby (when used in the mother), leading to learning or behavior problems later in life. Long surgeries or repeated procedures pose the highest risks.

Ask a doctor if it is safe to breastfeed shortly after you receive pentobarbital.

Relate drugs

How to use Pentobarbital injection

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Pentobarbital may be habit-forming. Never share pentobarbital with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Pentobarbital is injected into a muscle, or into a vein through an IV. A healthcare provider will usually give you this injection.

You may be shown how to use pentobarbital at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

When injected into a vein, pentobarbital must be given slowly.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely after you receive pentobarbital in a hospital setting.

Do not use pentobarbital if it has changed colors or has particles in it. Call your pharmacist for new medication.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

If you use this medicine long-term, you may need frequent medical tests.

Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using pentobarbital.

Store at room temperature away from moisture and heat. Do not freeze.

Warnings

You should not use phenobarbital if you have severe liver disease or a history of addiction to drugs similar to phenobarbital.

What other drugs will affect Pentobarbital injection

Using pentobarbital with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can affect pentobarbital, especially:

doxycycline;

griseofulvin;

birth control pills or hormone replacement estrogens;

a blood thinner--warfarin, Coumadin, Jantoven;

an MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others;

other seizure medications--divalproex, phenytoin, valproic acid; or

steroid medicine--prednisone, Dexamethasone, prednisolone, and others.

This list is not complete and many other drugs may affect pentobarbital. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.