Pertuzumab, trastuzumab, and hyaluronidase-zzxf
Generic name: Pertuzumab, Trastuzumab, And Hyaluronidase-zzxf
Drug class:
HER2 inhibitors
Usage of Pertuzumab, trastuzumab, and hyaluronidase-zzxf
Pertuzumab, trastuzumab, and hyaluronidase-zzxf combination injection is used first together with other cancer medicines to treat HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either greater than 2 centimeters in diameter or node positive) as part of a complete treatment plan for early breast cancer. It is also used after an initial treatment plan to treat HER2-positive early breast cancer which has a high risk of occurring again.
Pertuzumab, trastuzumab, and hyaluronidase-zzxf combination injection is also used together with docetaxel to treat HER2-positive metastatic (cancer that has spread) breast cancer in patients who have not previously received cancer treatment.
Pertuzumab, trastuzumab, and hyaluronidase-zzxf combination prevents the growth of some tumors that produce extra amounts of a certain substance known as the HER2 protein. It should only be used in patients whose tumors have been shown to produce extra amounts of this protein (HER2 overexpression).
This medicine is to be given only by or under the direct supervision of your doctor.
Pertuzumab, trastuzumab, and hyaluronidase-zzxf side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Less common
Rare
Incidence not known
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Before taking Pertuzumab, trastuzumab, and hyaluronidase-zzxf
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of pertuzumab, trastuzumab, and hyaluronidase-zzxf combination injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pertuzumab, trastuzumab, and hyaluronidase-zzxf combination injection in the elderly. However, elderly patients are more likely to have age-related heart problems and other unwanted effects (eg, decreased appetite and weight, burning, numbness, tingling, or painful feeling of the skin, lack or loss of strength), which may require caution in patients receiving this medicine.
Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Relate drugs
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- Herzuma
- Herzuma (Trastuzumab Intravenous)
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- Hyaluronidase and trastuzumab
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- Perjeta
- Pertuzumab
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- Phesgo
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- Trastuzumab and hyaluronidase-oysk
- Trastuzumab-anns
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- Trazimera
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How to use Pertuzumab, trastuzumab, and hyaluronidase-zzxf
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
A doctor or other trained health professional will give you this medicine in a medical facility. It is given as a shot under the skin of your thigh for at least 8 minutes for the initial dose then for at least 5 minutes once every 3 weeks.
Your doctor may want you stay for at least 15 to 30 minutes after each injection to check for unwanted effects.
You may also receive other medicines (including allergy medicine, fever medicine, pain medicine) before starting treatment with this medicine to help prevent unwanted effects.
Missed Dose
This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Warnings
It is very important that your doctor check your progress closely and at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start receiving this medicine to make sure you are not pregnant. You should use an effective form of birth control during treatment and for at least 7 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.
This medicine may cause heart problems, including heart failure, thickening of the heart, heart rhythm problems, or high blood pressure. Your doctor may test your heart before and during treatment with this medicine. Contact your doctor right away if you experience any chest pain, fast, slow, or uneven heartbeat, increased coughing, trouble with breathing, a sudden difficulty with breathing at night, rapid weight gain, swelling in your ankles or legs, blurred vision, dizziness, or headache.
You may also have an increased risk of having heart problems if you receive an anthracycline medicine after treatment with this medicine. You should not receive an anthracycline medicine for up to 7 months after stopping treatment with this medicine.
Serious lung or breathing problems may occur after you receive this medicine and could be life-threatening. Check with your doctor right away if have changes in your breathing, chest tightness, or any type of breathing problem.
This medicine can temporarily lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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