Phenergan w/Codeine

Generic name: Promethazine And Codeine
Drug class: Upper respiratory combinations

Usage of Phenergan w/Codeine

Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold.

Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronChial tubes (air passages of the lungs) and make breathing difficult. Codeine belongs to the group of medicine called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

This medicine is available only with your doctor's prescription.

Phenergan w/Codeine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Bluish lips or skin

chills

clay-colored stools

cold sweats

confusion

cough

dark urine

decrease in the frequency of urination

decrease in the urine volume

diarrhea

difficult or troubled breathing

difficulty in passing urine (dribbling)

dizziness

dizziness, faintness, or lightheadedness when getting up from lying or sitting position

fast, pounding, or irregular heartbeat or pulse

feeling of warmth

fever

headache

high fever

hives or welts, itching, or rash

increased sweating

irregular, fast or slow, or shallow breathing

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

loss of bladder control

nausea

noisy breathing

not breathing

painful urination

pale or blue lips, fingernails, or skin

rectal bleeding

redness of the face, neck, arms, and occasionally, upper chest

redness of the skin

seeing, hearing, or feeling things that are not there

seizures

severe muscle stiffness

shakiness in the legs, arms, or hands

stomach pain

sweating

tightness in the chest

tiredness

trembling or shaking of the hands or feet

unpleasant breath odor

unusual tiredness or weakness

unusually pale skin

vomiting of blood

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Cold, clammy skin

dry mouth

fainting

no blood pressure or pulse

no muscle tone or movement

pinpoint pupils (black part of the eye)

stopping of the heart

unconsciousness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bad dreams

blurred or loss of vision

confusion as to time, place, or person

continuing ringing or buzzing or other unexplained noise in the ears

difficulty having a bowel movement

disturbed color perception

double vision

drowsiness

false or unusual sense of well-being

halos around lights

hearing loss

holding false beliefs that cannot be changed by fact

increased sensitivity of the skin to sunlight

night blindness

overbright appearance of lights

redness or other discoloration of the skin

relaxed and calm feeling

severe sunburn

sleepiness

trouble sleeping

tunnel vision

unusual excitement, nervousness, or restlessness

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Phenergan w/Codeine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of promethazine and codeine combination is not recommended in children younger than 6 years of age for syrup or in children younger than 12 years of age for oral solution, because of the increased risk of respiratory depression.

Promethazine and codeine combination should not be used to relieve pain after surgery to remove tonsils or adenoids in any children. Severe breathing problems and deaths have been reported in some children who received codeine after tonsil or adenoid surgery.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of promethazine and codeine combination in the elderly. However, elderly patients are more likely to have unwanted effects (eg, confusion, drowsiness) and age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Bromopride

Calcium Oxybate

Cisapride

Dronedarone

Furazolidone

Iproniazid

Isocarboxazid

Levoketoconazole

Linezolid

Magnesium Oxybate

Mesoridazine

Methylene Blue

Moclobemide

Nalmefene

Naltrexone

Nialamide

Ozanimod

Phenelzine

Pimozide

Piperaquine

Potassium Citrate

Potassium Oxybate

Procarbazine

Rasagiline

Safinamide

Samidorphan

Saquinavir

Selegiline

Sodium Oxybate

Sparfloxacin

Terfenadine

Thioridazine

Toloxatone

Tranylcypromine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir

Abiraterone Acetate

Acepromazine

Aclidinium

Adagrasib

Alfentanil

Alfuzosin

Almotriptan

Alosetron

Alprazolam

Amantadine

Amifampridine

Amiloride

Amineptine

Amiodarone

Amisulpride

Amitriptyline

Amitriptylinoxide

Amobarbital

Amoxapine

Amphetamine

Amprenavir

Anagrelide

Anileridine

Apalutamide

Apomorphine

Aprepitant

Aripiprazole

Aripiprazole Lauroxil

Armodafinil

Arsenic Trioxide

Asenapine

Astemizole

Atazanavir

Atropine

Azithromycin

Baclofen

Belladonna

Bemetizide

Bendroflumethiazide

Benperidol

Bentazepam

Benzhydrocodone

Benzphetamine

Benzthiazide

Benztropine

Biperiden

Boceprevir

Bosentan

Bromazepam

Bromopride

Bumetanide

Buserelin

Butorphanol

Calcium Oxybate

Cannabidiol

Cannabis

Canrenoate

Canrenone

Carbamazepine

Carbinoxamine

Carisoprodol

Carphenazine

Cenobamate

Chloral Hydrate

Chlorothiazide

Chlorpheniramine

Chlorpromazine

Chlorthalidone

Chlorzoxazone

Cimetidine

CinaCalcet

Ciprofloxacin

Citalopram

Clarithromycin

Clemastine

Clidinium

Clobazam

Clofazimine

Clomipramine

Clonazepam

Clopamide

Clopidogrel

Clorazepate

Clothiapine

Cloxazolam

Clozapine

Cobicistat

Cocaine

Codeine

Conivaptan

Crizotinib

Cyclobenzaprine

Cyclopenthiazide

Cyclopentolate

Cyclosporine

Cyclothiazide

Cyproheptadine

Dabrafenib

Daridorexant

Darifenacin

Darunavir

Dasatinib

Degarelix

Delamanid

Delavirdine

Delorazepam

Desipramine

Deslorelin

Desmopressin

Desvenlafaxine

Deutetrabenazine

Dexamethasone

Dexmedetomidine

Dextroamphetamine

Dextromethorphan

Dezocine

Diacetylmorphine

Diazepam

Diazoxide

Dibenzepin

Dichloralphenazone

Dicyclomine

Difenoxin

Dihydrocodeine

Diltiazem

Dimenhydrinate

Diphenhydramine

Diphenoxylate

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxepin

Doxylamine

Dronedarone

Droperidol

Duloxetine

Efavirenz

Elagolix

Eletriptan

Encorafenib

Enflurane

Entrectinib

Enzalutamide

Epinephrine

Eplerenone

Erythromycin

Escitalopram

Esketamine

Eslicarbazepine Acetate

Estazolam

Eszopiclone

Ethacrynic Acid

Ethchlorvynol

Ethopropazine

Ethylmorphine

Etozolin

Etrasimod

Etravirine

Fedratinib

Fenfluramine

Fentanyl

Fesoterodine

Fexinidazole

Fingolimod

Flavoxate

Flecainide

Flibanserin

Fluconazole

Flunitrazepam

Fluoxetine

Fluphenazine

Flurazepam

Fluspirilene

Fluvoxamine

Formoterol

Fosamprenavir

Fosaprepitant

Foscarnet

Fosnetupitant

Fosphenytoin

Fospropofol

Fostemsavir

Frovatriptan

Furosemide

Gabapentin

Gabapentin Enacarbil

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Glucagon

Glycopyrrolate

Glycopyrronium Tosylate

Gonadorelin

Goserelin

Granisetron

Halazepam

Halofantrine

Haloperidol

Halothane

Hexobarbital

Histrelin

Homatropine

Hydrochlorothiazide

Hydrocodone

Hydroflumethiazide

Hydromorphone

Hydroxychloroquine

Hydroxytryptophan

Hydroxyzine

Hyoscyamine

Ibutilide

Idelalisib

Iloperidone

Imatinib

Imipramine

Indapamide

Indinavir

Inotuzumab Ozogamicin

Ipratropium

Isoflurane

Isradipine

Itraconazole

Ivabradine

Ivacaftor

Ivosidenib

Ketamine

Ketazolam

Ketobemidone

Ketoconazole

Lacosamide

Lapatinib

Larotrectinib

Lasmiditan

Lefamulin

Lemborexant

Lenacapavir

Lenvatinib

Letermovir

Leuprolide

Levocetirizine

Levofloxacin

Levomilnacipran

Levorphanol

Lisdexamfetamine

Lithium

Lofepramine

Lofexidine

Lomitapide

Lopinavir

Loprazolam

Lorazepam

Lorcaserin

Lorlatinib

Lormetazepam

Loxapine

Lumacaftor

Lumefantrine

Macimorelin

Magnesium Oxybate

Mavacamten

Meclizine

Medazepam

Mefloquine

Melitracen

Melperone

Mepenzolate

Meperidine

Mephobarbital

Meprobamate

Meptazinol

Mesoridazine

Metaclazepam

Metaxalone

Methacholine

Methadone

Methamphetamine

Methdilazine

Methocarbamol

Methohexital

Methotrimeprazine

Methyclothiazide

Metoclopramide

Metolazone

Metrizamide

Metronidazole

Mibefradil

Midazolam

Mifepristone

Milnacipran

Mirabegron

Mirtazapine

Mitotane

Mobocertinib

Modafinil

Molindone

Moricizine

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Nafarelin

Nafcillin

Nalbuphine

Naratriptan

Nefazodone

Nelfinavir

Netupitant

Nevirapine

Nicomorphine

Nilotinib

Nitrazepam

Nitrous Oxide

Nordazepam

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Omaveloxolone

Ondansetron

Opipramol

Opium

Opium Alkaloids

Orphenadrine

Osilodrostat

Osimertinib

Oxaliplatin

Oxazepam

Oxcarbazepine

Oxitropium Bromide

Oxybutynin

Oxycodone

Oxymorphone

Ozanimod

Pacritinib

Palbociclib

Paliperidone

Palonosetron

Panobinostat

Papaveretum

Paregoric

Paroxetine

Pasireotide

Pazopanib

Pentamidine

Pentazocine

Pentobarbital

Perampanel

Perazine

Periciazine

Perphenazine

Phenobarbital

Phenytoin

Pimavanserin

Pinazepam

Pipenzolate Bromide

Piperacetazine

Pipotiazine

Pirenzepine

Piretanide

Piritramide

Pitolisant

Polythiazide

Ponesimod

Porfimer

Posaconazole

Potassium Oxybate

Prazepam

Prednisone

Pregabalin

Primidone

Procainamide

Procarbazine

Prochlorperazine

Procyclidine

Promazine

Promethazine

Propafenone

Propantheline

Propiverine

Propofol

Protriptyline

Quazepam

Quetiapine

Quinethazone

Quinidine

Quinine

Quizartinib

Ramelteon

Ranitidine

Ranolazine

Relugolix

Remifentanil

Remimazolam

Remoxipride

Revefenacin

Ribociclib

Rifabutin

Rifampin

Rifapentine

Ritonavir

Rizatriptan

Rolapitant

Ropeginterferon Alfa-2b-njft

Saquinavir

Scopolamine

Secobarbital

Secretin Human

Selpercatinib

Sertindole

Sertraline

Sevoflurane

Sibutramine

Siponimod

Sodium Oxybate

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Spironolactone

St John's Wort

Stramonium

Sufentanil

Sulpiride

Sumatriptan

Sunitinib

Suvorexant

Tacrolimus

Tapentadol

Telaprevir

Telavancin

Telithromycin

Temazepam

Terbinafine

Terodiline

Tetrabenazine

Tetrazepam

Thiethylperazine

Thiopental

Thiopropazate

Thioridazine

Thiothixene

Tianeptine

Tilidine

Tiotropium

Tizanidine

Tocilizumab

Tolonium Chloride

Tolterodine

Topiramate

Toremifene

Torsemide

Tramadol

Trazodone

Triamterene

Triazolam

Trichlormethiazide

Triclabendazole

Trifluoperazine

Trifluperidol

Triflupromazine

Trihexyphenidyl

Trimeprazine

Trimipramine

Triptorelin

Tropicamide

Trospium

Tryptophan

Umeclidinium

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Verapamil

Vilanterol

Vilazodone

Vinflunine

Voclosporin

Voriconazole

Vortioxetine

Voxelotor

Xipamide

Zaleplon

Ziprasidone

Zolmitriptan

Zolpidem

Zopiclone

Zotepine

Zuclopenthixol

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aminolevulinic Acid

Belladonna

Belladonna Alkaloids

Betel Nut

Evening Primrose

Midodrine

Phenylalanine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Relate drugs

How to use Phenergan w/Codeine

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming and cause mental or physical dependence.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For relief of symptoms caused by allergies or the common cold:

For oral dosage form (solution):

Adults and children 12 years of age and older—5 milliliters (mL) (1 teaspoonful) every 4 to 6 hours. Do not take more than 30 mL in 24 hours.

Children younger than 12 years of age—Use is not recommended.

For oral dosage form (syrup):

Adults and children 12 years of age and older—5 milliliters (mL) (1 teaspoonful) every 4 to 6 hours. Do not take more than 30 mL in 24 hours.

Children 6 to 11 years of age—2.5 to 5 mL (0.5 to 1 teaspoonful) every 4 to 6 hours. Do not take more than 30 mL in 24 hours.

Children younger than 6 years of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

Warnings

It is very important that your doctor check your or your child's progress while taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

If your condition does not improve or becomes worse, check with your doctor.

Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". As a result, there may be too much morphine in the body and more side effects from morphine than usual. Children may be especially sensitive to this effect. Do not give this medicine to:

Children younger than 12 years of age.

Children younger than 18 years of age who have had surgery removal of tonsils or adenoids.

Children 12 to 18 years of age who have a high risk for breathing problems (eg, obstructive sleep apnea, obesity, lung disease).

If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to morphine overdose in the nursing baby and cause very serious side effects.

For nursing mothers taking this medicine:

Talk to your doctor if you have any questions about taking codeine or about how this medicine may affect your baby.

Call your doctor if you become extremely tired and have difficulty caring for your baby.

Your baby should generally nurse every 2 to 3 hours and should not sleep for more than 4 hours at a time.

Check with your doctor or hospital emergency room immediately if your baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, difficulty breathing, or limpness. These may be symptoms of an overdose and need immediate medical attention.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when getting up suddenly from a lying or sitting position, so stand up slowly.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you or your child are using this medicine.

Promethazine may increase your risk for convulsions (seizures). It may also cause dystonia (movement disorder). This is more likely in sick children with diarrhea. Talk to your doctor if you have any concerns.

Check with your doctor right away if you or your child are having convulsions, difficulty in breathing, fast heartbeat, high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

If you think you or your child may have taken an overdose of this medicine, get emergency help at once. Signs of an overdose include extreme sleepiness, confusion, shallow breathing, hallucinations, nausea, vomiting, pinpoint pupils of the eyes, pale or blue lips, fingernails, or skin, or seizures.

Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine.

This medicine may make your skin more sensitive to sunlight. Use sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

This medicine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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