Phentermine and topiramate

Generic name: Phentermine And Topiramate
Brand names: Qsymia
Dosage form: oral capsule, extended release (11.25 mg-69 mg; 15 mg-92 mg; 3.75 mg-23 mg; 7.5 mg-46 mg)
Drug class: Anorexiants

Usage of Phentermine and topiramate

Phentermine and topiramate is a combination medicine used together with diet and exercise to treat obesity in people 12 years and older.

phentermine and topiramate is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Phentermine and topiramate will not treat these underlying conditions. Keep using any other medicines your doctor has prescribed.

Phentermine and topiramate may also be used for purposes not listed in this medication guide.

Phentermine and topiramate side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Phentermine and topiramate may cause serious side effects. Call your doctor at once if you have:

unusual changes in mood or behavior;

confusion, trouble concentrating, problems with speech or memory;

fast or pounding heartbeats while you are resting;

a seizure;

signs of a kidney stone--severe pain in your side or lower back, painful or difficult urination; or

signs of too much acid in your blood--loss of appetite, tiredness, thinking problems, irregular heartbeats.

Common side effects of phentermine and topiramate may include:

joint pain, ankle sprain;

flu-like symptoms;

dizziness;

constipation;

numbness or tingly feeling;

sleep problems (insomnia);

dry mouth, changes in your sense of taste; or

mood changes, feelings of low self-worth, loss of interest in things you once enjoyed, thoughts about hurting yourself.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Phentermine and topiramate

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to phentermine or topiramate, or if you have:

glaucoma;

overactive thyroid; or

if you are pregnant or may become pregnant.

You may need to have a negative pregnancy test before starting this treatment. Do not use phentermine and topiramate if you are pregnant. Stop taking this medicine and call your doctor right away if you become pregnant.

Topiramate may increase the risk of cleft lip and palate in a newborn. This birth defect occurs early in pregnancy, and can develop even before you know you are pregnant. Weight loss during pregnancy also can harm an unborn baby, even if you are overweight. Use effective birth control to prevent pregnancy while you are using phentermine and topiramate.

Taking this medicine together with birth control pills may cause breakthrough bleeding (spotting). However, this is unlikely to make your birth control pills less effective in preventing pregnancy. If you have spotting or irregular bleeding, keep taking your birth control pills and talk with your doctor.

Tell your doctor if you have ever had:

heart problems, high blood pressure;

a heart attack or stroke;

diabetes (weight loss may cause low blood sugar);

metabolic acidosis (too much acid in your blood);

soft or brittle bones (osteomalacia, osteopenia, osteoporosis);

kidney disease, kidney stones, or dialysis;

liver disease;

mood problems, depression, or suicidal thoughts or actions;

an allergy to aspirin or yellow dye (tartrazine);

a seizure; or

chronic diarrhea.

Topiramate can increase the level of acid in your blood (metabolic acidosis). This can weaken your bones, cause kidney stones, or cause growth problems in children or harm to an unborn baby. You may need blood tests to make sure you do not have metabolic acidosis.

Some people have thoughts about suicide while taking topiramate. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

You should not breastfeed while using this medicine.

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How to use Phentermine and topiramate

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take phentermine and topiramate each morning, with or without food.

Drink plenty of water each day to prevent dehydration or kidney stones while you are taking phentermine and topiramate.

Your doctor may change your dose or tell you to stop taking this medicine if you have not lost a certain amount of weight during the first 12 weeks. Follow your doctor's dosing instructions very carefully. You must also follow a low-calorie diet.

Do not stop using phentermine and topiramate suddenly or you could have a seizure (convulsions). Follow your doctor's instructions about tapering your dose.

Phentermine and topiramate can increase your resting heart rate. Your doctor will need to check your heart function.

Store at room temperature away from moisture and heat.

Phentermine may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Warnings

Do not use if you are pregnant or if you become pregnant. phentermine and topiramate may increase the risk of a birth defect called cleft lip and palate in a newborn.

Phentermine and topiramate can increase your resting heart rate. Tell your doctor if you have fast or pounding heartbeats while you are resting.

Topiramate may cause vision problems that can be permanent if not treated quickly. Call your doctor right away if you have a sudden decrease in vision.

Some people have thoughts about suicide while taking topiramate. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What other drugs will affect Phentermine and topiramate

Phentermine and topiramate can cause irregular vaginal bleeding while you are taking birth control pills. This should not make the pills less effective in preventing pregnancy.

Using this medicine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

acetazolamide;

methazolamide;

zonisamide;

valproic acid or divalproex sodium (Depakene or Depakote)

birth control pills;

a diuretic or "water pill"; or

insulin or oral diabetes medicine.

This list is not complete. Other drugs may affect phentermine and topiramate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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