Portrazza

Generic name: Necitumumab
Drug class: EGFR inhibitors

Usage of Portrazza

Portrazza is a monoclonal antibody that blocks a certain protein in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Portrazza is used to treat a certain type of non-small cell lung cancer. This medicine is usually given in combination with other cancer medications.

Portrazza may also be used for purposes not listed in this medication guide.

Portrazza side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel chilled or feverish, or if you have trouble breathing.

Portrazza may cause serious side effects. Call your doctor at once if you have:

  • acne-like skin rash;
  • thickened skin or a hard lump where the medicine was injected;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
  • chest pain or pressure, pain spreading to your jaw or shoulder;
  • signs of a blood clot--sudden numbness or weakness, problems with vision or speech, sudden cough, wheezing, coughing up blood, pain or swelling in an arm or leg; or
  • symptoms of an electrolyte imbalance--numbness or tingling, irregular heartbeats, muscle tightness, tremors, muscle weakness or limp feeling, leg cramps, increased thirst or urination, behavior changes, seizure (convulsions).
  • Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

    Common side effects of Portrazza may include:

  • vomiting, diarrhea;
  • skin rash; or
  • low levels of magnesium in your blood.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Portrazza

    You should not be treated with Portrazza if you are allergic to it.

    To make sure Portrazza is safe for you, tell your doctor if you have:

  • coronary artery disease (hardened arteries);
  • high blood pressure;
  • chronic obstructive pulmonary disease (COPD);
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
  • a history of heart attack or stroke.
  • Using Portrazza during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are using Portrazza and for at least 3 months after your last dose.

    It is not known whether necitumumab passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are being treated with necitumumab, and for at least 3 months after your last dose.

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    How to use Portrazza

    Portrazza is injected into a vein through an IV. A healthcare provider will give you this injection. This medicine must be injected slowly, and the IV infusion can take at least 1 hour to complete.

    Portrazza is given in a 21-day treatment cycle. You may need to use the medicine only on days 1 and 8 of each cycle. Your doctor will determine how long to treat you with this medicine.

    You may be given medication to prevent certain side effects while you are receiving Portrazza.

    Portrazza can cause your electrolytes to become unbalanced. This can lead to serious heart problems, including cardiac arrest. You will need frequent blood tests to check your electrolytes (calcium, potassium, and magnesium).

    Your doctor may recommend that you take mineral supplements to keep your electrolytes from getting too low. Follow your doctor's dosing instructions very carefully.

    Portrazza can have long-lasting effects on your body. You may need frequent medical tests for at least 8 weeks after you stop using this medicine.

    Warnings

    Portrazza can cause your electrolytes to become unbalanced. This can lead to serious heart problems, including cardiac arrest. You will need frequent blood tests to check your electrolytes (calcium, potassium, and magnesium).

    What other drugs will affect Portrazza

    Other drugs may interact with necitumumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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